Ashley M. Buckle

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

This study constructs a comprehensive phylogeny of 6000 serpin sequences across all kingdoms of life, showing convergent evolution rather than horizontal gene transfer for the central hub proteins.

This paper identifies limitations in mainstream methods for detecting network motifs in biology, showing they fail to distinguish true motifs from spurious results due to flawed statistical assumptions.

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

This study identifies a metal-dependent regulatory mechanism in PfA-M17 aminopeptidase, showing how oligomerization and metal center re-modelling control proteolytic activity.