Genetics, Aging, and Longevity in Model Organisms

The paper analyzes proteomic changes across 10 tissues in mice at different ages, finding age-related increases in immune proteins and tissue-specific alterations in protein complexes.

This study uses network analysis in Drosophila melanogaster to identify mitochondrial genes associated with aging and age-related diseases.

This study identifies HPK-1 as a neuronal transcriptional regulator that maintains proteostasis and extends longevity in C. elegans by modulating serotonergic and GABAergic pathways.

This study shows that mutating APRT in turquoise killifish extends male lifespan and improves metabolic health, with mitochondrial function and AMPK activity playing key roles.

voyAGEr provides a web tool to analyze age-related gene expression changes in 49 human tissues using GTEx RNA-seq data, enabling visualization and statistical exploration of sex- and tissue-specific transcriptomic alterations.

This study identifies daf-42 as an essential gene for dauer development in C. elegans, showing it is evolutionarily young and critical for survival under adverse conditions.

This study shows that disrupting TBC-2 reduces lifespan and stress resistance in long-lived mitochondrial mutants in C. elegans, suggesting a role for endosomal trafficking in mitochondrial dysfunction-related longevity.

This study shows that a specific diet, Lactobacillus reuteri, can preserve associative learning in aged C. elegans through DAF-16 pathway activation without affecting lifespan.

This study shows serotonin signaling improves oocyte quality in C. elegans and D. melanogaster, suggesting a conserved role in germline health and potential therapeutic applications.

The paper investigates how knocking out nuclear-encoded mitochondrial genes in yeast affects lifespan, revealing shared mechanisms involving ribosomal proteins, actin dynamics, and proteasome function.

This study investigates the role of retrotransposon expression and insertions in aging using Drosophila, finding that expression, not insertion, is linked to longevity.

This study shows biological age can increase with stress and decrease with recovery, using epigenetic clocks in mice and humans.

The paper shows that reaction norm variation explains inconsistent results in dietary restriction studies and highlights the need for personalized approaches in ageing research.

TRAIL quantifies protein and cell lifetimes across tissues, showing cell division drives non-selective turnover in proliferative tissues while physicochemical features influence turnover in non-proliferative tissues.

The paper identifies the transcriptional activation of Jun and Fos genes in the AP-1 complex as a conserved aging signature in immune cells, contributing to inflammaging across mouse strains and humans.

This study quantifies DAF-16 spatiotemporal activity in C. elegans under dietary restriction and finds it predicts lifespan extension with 78% accuracy.

This study investigates how myriocin, a sphingolipid biosynthesis inhibitor, enhances longevity by modulating ubiquitination and proteostasis networks in yeast.

This study shows that piRNA pathway downregulation in the germline during mating releases Hedgehog signaling, leading to somatic aging and reduced lifespan.

The paper examines nine long-lived C. elegans mutants to show a strong correlation between stress resistance and longevity, driven by overlapping genetic pathways.

The paper identifies a systemic age-dependent transcriptome imbalance driven by transcript length across multiple species and shows its correlation with splicing factors and environmental stressors.

The paper shows that ROS and gene-expression dynamics set limits on yeast cell cycle progression at near-freezing temperatures.

The paper measures damage and repair rates in aging mice and humans, finding that robustness and resilience decline with age, with robustness having a greater impact on damage accumulation.

The paper examines age-related changes in small RNA abundance and RISC loading in Drosophila, finding stability in small RNA levels but age-related effects on miRNA RISC loading.

This paper develops a deep learning model to identify a blood-based biomarker of aging in mice using phenotypic data, finding it correlates with aging hallmarks and predicts lifespan.

This study investigates the role of Tra1 in yeast chronological aging, finding it regulates stress response genes and mitochondrial function, impacting longevity.

This study combines stem cell rejuvenation and senescent cell clearance to synergistically extend lifespan and improve healthspan in organisms.

This study shows C. elegans uses temperature-sensing neurons to preemptively activate defenses against hydrogen peroxide, which becomes more reactive at higher temperatures.

The paper identifies conserved healthspan-related gene modules across species using co-expression network analysis and meta-analysis of transcriptomic data.

The paper shows that during starvation, somatic cells rely on active transcription for survival while germline cells use transcriptional quiescence and mRNA stability to preserve reproductive potential in C. elegans.

The paper develops a hierarchical process model to link behavioral aging and lifespan in C. elegans, revealing two distinct but coupled physical declines that influence aging and longevity.