Michael T. Marr

This study shows that the intrinsically disordered N-terminal region of eIF5B drives RNA-driven phase separation in vitro and validates this in cells.

The paper acutely depletes EIF4G1 in human cells and identifies transcript-specific effects on translation and ribosome quality control.

The paper shows that the 5' UTRs of Insr and Igf1r transcripts support translation initiation independently of eIF4G1 in both in vitro and cellular settings.

The paper examines age-related changes in small RNA abundance and RISC loading in Drosophila, finding stability in small RNA levels but age-related effects on miRNA RISC loading.

This study shows that artificially stimulating retrotransposon activity in Drosophila reduces lifespan and accelerates some aging phenotypes, with dFOXO partially rescuing these effects.