Genetics, Aging, and Longevity in Model Organisms

This study examines how dauer formation and L1 arrest in C. elegans affect population resilience under stress, showing that daf-16 and daf-22 mutants have different recovery abilities and stage distributions compared to wild type.

This study identifies DAF-16/FOXO's role in repressing let-7 microRNA and NHR-23 to maintain multipotency during dauer in C. elegans.

This study shows that deleting the Nepl15 gene in Drosophila improves anti-aging and anti-obesity traits, with stronger effects in females than males.

This study shows that the longevity of C. elegans Eat mutants is mostly due to reduced bacterial infection rather than dietary restriction.

This study shows that pantothenate supplementation improves stress resistance and extends lifespan in C. elegans by enhancing coenzyme A metabolism through DAF-16 and pnk-1 pathways.

InferAging quantifies biological aging by modeling deviations from chronological age, identifying accelerated and delayed agers in zebrafish using non-invasive phenotypes.

This study shows that insulin signaling modulates the genomic response to aging and heat stress by switching between modular and integrated regulatory states in Drosophila.

This study shows that Canagliflozin's neuroprotective effects in aging mice are sex-specific, with males benefiting more despite females having higher drug concentrations.

This study identifies molecular mechanisms by which C. elegans avoid Methylobacterium after ingestion, integrating lipid metabolism and dietary needs to influence food preference.

The paper shows that diacetyl, a volatile food cue, induces the DHAP-Glycerol shunt and fmo-2 expression in C. elegans, linking olfactory signals to metabolic and behavioral responses.

This study presents a single-nucleus transcriptomic atlas of Drosophila treated with rapamycin, identifying a sex-biased convergent aging trajectory and its modulation by rapamycin.

This study shows that nematocin, an oxytocin/vasopressin-like neuropeptide in C. elegans, regulates intestinal lipid metabolism and reproductive output during aging.

This study identifies shared metabolic changes across five longevity interventions in mice, highlighting ergothioneine and lipid remodeling as key features.

This study investigates the conservation of dietary restriction (DR) mechanisms across Drosophila species, finding phenotypic conservation but taxonomic specificity in genetic responses.

This study shows that DNA methylation from fecal samples accurately reflects molecular aging in wild capuchin monkeys, revealing age-related epigenetic changes linked to cellular damage and inflammation.

This study shows that combining methionine restriction, taurine supplementation, and exercise in fruit flies extends lifespan without compromising health or function.

This study compares senescence patterns in two Pristionchus nematode species, identifying both conserved and diverged age-related traits.

This paper introduces a computational framework to quantify transcriptomic damage across tissues and conditions, revealing age-associated increases and demonstrating that interventions can alter tDamAge.

This paper develops a self-supervised model to predict aging and lifespan from behavioral data in killifish, finding that single-day predictions can match whole-life models for some traits.

This paper shows that LOESS and DE-SWAN can create false 'waves' of molecular aging in data, challenging their statistical validity.

The paper estimates human lifespan limits by modeling the impact of somatic mutations, finding they reduce lifespan from 430 to 169 years but cannot fully explain mortality.

This study shows curcumin and sulforaphane improve mobility in aging C. elegans through distinct transcriptional mechanisms, with their combination enhancing detoxification and reducing immune gene expression.

This study identifies shared age-associated pathway remodeling across species using comparative metabolomics, highlighting lipid and nucleotide pathways as core features of aging.

This study investigates how survival curve shapes change with aging in C. elegans and finds that rectangularization and triangularization reflect different patterns of healthspan and morbidity expansion.

This paper proposes the Metabolic Scope Theory of Aging (MSTA) to explain lifespan variation by linking mitochondrial bioenergetic reserve, stability, and pace across species.

This study shows that the snf1Δ strain of S. cerevisiae exhibits altered chronological aging and increased competitiveness under different nutrient conditions, mirroring cancer cell behavior.

This study shows that calorie restriction induces daily torpor in mice, causing DNA damage that is repaired during arousal, and that cooling during arousal inhibits DNA repair.

This study examines how oxidative stress and aging affect neuromuscular function in Drosophila by analyzing nerve conduction, synaptic transmission, and muscle excitability in a male-specific abdominal neuromuscular junction.

This study identifies the Neotropical butterfly genus Heliconius as a model for studying longevity evolution, finding heritable mechanisms of slowed ageing in long-lived species.