ImmunologybioRxivPreprint
Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses
Ariel Floro, Ritesh Tiwari, Mitsunori Nomura…·Eric M. Verdin
DOI 10.64898/2026.04.20.718782
Author
Durai Sellegounder
Buck Institute for Research on AgingORCID 0000-0002-0776-0307Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2023-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 23 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- Systems BiologybioRxivPreprint
Curcumin and Sulforaphane Preserve Mobility in Aging Caenorhabditis elegans via Distinct yet Complementary Transcriptional Signatures
R.P. Vivek-Ananth, Durai Sellegounder, Karthik Mohanraj…·Nathan D. Price
This study shows curcumin and sulforaphane improve mobility in aging C. elegans through distinct transcriptional mechanisms, with their combination enhancing detoxification and reducing immune gene expression.
DOI 10.64898/2026.06.23.734065 - Molecular BiologyCell ReportsPeer-reviewed
Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.
Lauren A. Wimer, Kiyomi Raye Kaneshiro, Jessica Ramirez…·Pankaj Kapahi
Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.
5 citations - NeurosciencebioRxivPreprint
Pathogenic tau inhibits synaptic plasticity by blocking eIF4B-mediated local protein synthesis
2 citations - GeneticseLifePeer-reviewed
Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans
Muniesh Muthaiyan Shanmugam, Jyotiska Chaudhuri, Durai Sellegounder…·Pankaj Kapahi
This study identifies MG-H1 as a mediator of increased food intake in C. elegans glod-4 mutants through a tyramine signaling pathway regulated by the GATA transcription factor ELT-3.
11 citations