Forensic and Genetic Research

This paper introduces a method to estimate genome-wide genealogies for thousands of samples, revealing new insights into human evolutionary history and selection.

This study uses whole-genome sequences and genotypes from Yemenis to explore their genetic diversity and its relation to the Near East, finding limited geographic structure and widespread African admixture.

The paper reconstructs 9000 years of agricultural diet in Asia and shows its impact on genetic variation in 29 Asian populations, identifying genes related to metabolism as targets of dietary-driven selection.

This paper introduces a likelihood method to estimate present-day human contamination in ancient DNA samples using low-depth haploid chromosome data, showing improved accuracy compared to existing methods.

The paper analyzes 21 autosomal STRs from 543 Bahraini males using the GlobalFiler kit to assess genetic diversity and forensic parameters, finding most loci in HWE and SE33 as the most polymorphic marker.

The paper analyzes genomic data from Hmong-Mien-speaking populations to reveal an inland-coastal genetic split linked to agricultural expansion in southern China.

The paper examines mtDNA heteroplasmy sharing between human liver lobes, finding higher sharing in the control region and suggesting selection influences this pattern.

This paper shows reference bias affects ancient DNA studies and suggests filtering strategies to reduce its impact on population genomic analyses.

The paper investigates the genetic relationship between contemporary Bulgarians and Iron Age steppe dwellers from the Pontic-Caspian steppe, identifying a Caucasian genetic component introduced through migration.

This study analyzes runs of homozygosity in sub-Saharan African populations to uncover demographic history and health-related genetic variation.

The paper challenges previous interpretations of biparental mtDNA inheritance, proposing a model where paternal mtDNA undergoes selective fixation due to initial low copy number and a selective advantage.

The paper examines how changes in genetic admixture over time affect heterozygosity and health outcomes in a southeastern U.S. population.

The paper evaluates common misuses of PCA in SNP data analysis and recommends best practices for improving population structure elucidation.

This study analyzes genetic admixture in Argentinian Patagonia using 46 ancestry informative markers, revealing regional variations in Native American, European, and African ancestry contributions.

The paper develops a likelihood-based framework to infer demographic history using two-locus statistics, showing that models including archaic admixture better explain genetic diversity patterns.

This paper analyzes ancient genomes from northeastern Siberia to reveal complex population migrations and admixture events over the past 40,000 years.

The paper introduces new kinship and FST estimators, showing higher genetic differentiation in global human populations compared to existing methods.

This paper introduces an algorithm to infer ancestry segments and admixture events without prior knowledge of mixing groups, showing improved accuracy over existing methods.

ALStructure estimates population structure using a likelihood-free method that combines principal components analysis with admixture model constraints, outperforming existing methods in accuracy and speed.

This paper introduces a method for kinship estimation using large SNP panels, resolving parent-sibling relationships and distinguishing degrees of kinship.

The paper identifies phenotypic cues and genetic architecture underlying ancestry-based assortative mating in admixed Latin American populations using genome-wide haplotype analysis.

The paper shows the current Sibship Index fails to distinguish full-sibs from half-sibs and proposes a corrected index using maternal genotype to improve accuracy.

The paper analyzes paternal and maternal genetic histories of Thai and Lao populations, finding contrasting patterns of male and female genetic variation and demographic expansions.

The paper analyzes ancient DNA from the Balearic Islands, Sicily, and Sardinia to trace the arrival and spread of Steppe and Iranian-related ancestries in the western Mediterranean, revealing complex admixture histories.

This study uses ancient DNA to trace Sardinia's population history from the Neolithic to the present, finding genetic continuity and limited Bronze Age Steppe ancestry.

The paper analyzes ancient mitogenomes from the Canary Islands to trace the origin and migration patterns of indigenous populations, identifying new lineages and supporting a model of two distinct migrations.

The paper confirms a positive selection signal at the ABCA12 gene in Europeans and East-Asians and refines its genomic location, finding no direct effect on gene expression but tracing the T allele's trajectory in human history.

The paper analyzes ancient genomes from Anatolia to show genetic continuity between hunter-gatherers and early farmers, suggesting limited migration in the origin of farming in central Anatolia.

The paper analyzes the genome of a Jomon individual to infer migration patterns into East Asia, finding multiple waves and a coastal route from Southeast Asia.

This study optimizes a DNA forensic pipeline by modifying PCR and CE protocols to reduce STR analysis time for buccal cell samples from 97-102 to under 80 minutes.