Pancreatitis Pathology and Treatment

NIK stabilization reprograms the pancreas toward chronic pancreatitis and pancreatic lipomatosis

This study shows that NIK stabilization causes chronic pancreatitis and pancreatic lipomatosis via RelB-dependent non-canonical NF-κB signaling.

ST6GAL1 sialyltransferase promotes acinar cell survival and tissue regeneration during pancreatitis

This study identifies ST6GAL1 as a key mediator of acinar cell survival and tissue regeneration during pancreatitis by promoting cell survival pathways and tissue repair.

Multi-population genome-wide association meta-analysis of acute and chronic pancreatitis

This study performs a multi-population GWAS meta-analysis of acute and chronic pancreatitis, identifying genetic loci and potential therapeutic targets.

Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics

This study uses patient-derived organoids to identify CFTR modulators as a therapeutic strategy for chronic pancreatitis.

Sex-Dimorphic Neural Memory Shapes Pancreatic Tissue Resilience

The paper identifies a sex-specific neural memory mechanism in the pancreas that influences epithelial plasticity and tissue resilience after injury.

Serine Stabilizes SLC7A11 and Enhances Cystine Influx to Protect Against Acute Pancreatitis

This study shows serine stabilizes SLC7A11 and enhances cystine influx, reducing oxidative stress and pancreatic injury in acute pancreatitis.

Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice

This study shows that deficiency of MANF worsens acute pancreatitis in mice, with sex-specific effects on inflammation and oxidative stress.

Acinar-Derived VEGF-A Orchestrates Blood Vascular Remodeling and Preserves Microvessels During Acute Pancreatitis

This study shows that VEGF-A from acinar cells is crucial for vascular remodeling and preserving microvessels during acute pancreatitis.

Emodin-Enhanced hUC-MSC Extracellular Vesicles Alleviate Acute Pancreatitis by Targeting Inflammation and Pyroptosis

This study shows that emodin-loaded hUC-MSC extracellular vesicles improve cell viability, reduce inflammation, and inhibit pyroptosis in acute pancreatitis models.

Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic Pancreatitis

This study identifies CFTR-related defects in idiopathic pancreatitis and shows that ivacaftor can reverse these defects in patient-derived models.

PIN1 Drives Cellular Plasticity and Immune Modulation in Chronic Pancreatitis

This study shows PIN1 promotes cellular plasticity and immune changes in chronic pancreatitis, with genetic or pharmacological inhibition reducing disease severity.

Emodin: an alveolar macrophage protector in acute pancreatitis induced lung injury

This study investigates the protective role of emodin in acute pancreatitis-induced lung injury by examining its effects on alveolar macrophages, inflammation, pyroptosis, and mitophagy.

An Fc-SPINK1 fusion protein inhibits pancreatic inflammation in a mouse model

This paper develops an Fc-SPINK1 fusion protein that reduces pancreatic inflammation in mice by extending its half-life and inhibiting trypsin activity.

HMG Box-Containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic Progression.

This study shows HBP1 protects against acute pancreatitis but promotes pancreatic cancer progression in the presence of KRAS mutations.

Population dynamics after pancreatitis dictates long-lasting epigenetic reprogramming and mediates tumor predisposition

This study shows that acute pancreatitis induces epigenetic changes in acinar cells, leading to long-term tumor predisposition through altered cell states and plasticity.

The reversion variant (p.Arg90Leu) at the evolutionarily adaptive p.Arg90 site in CELA3B predisposes to chronic pancreatitis

The paper identifies p.Arg90Leu as a variant in CELA3B associated with chronic pancreatitis, reverting to an ancestral allele and confirming CELA3B's role in CP etiology.

Bile acid supplementation improves murine pancreatitis in association with the gut microbiota

This study shows that bile acid supplementation reduces pancreatic and intestinal injury in mice with acute pancreatitis, with effects potentially mediated by the gut microbiota.

Multiomic definition of generalizable endotypes in human acute pancreatitis

The paper identifies four distinct endotypes in acute pancreatitis using multiomic data and clinical metrics, showing diverse molecular and systemic responses.

SPINK1-induced amelioration of impaired autophagy contributes to suppression of trypsinogen activation in a model of acute pancreatitis

This study shows SPINK1 reduces trypsinogen activation in a pancreatitis model by improving impaired autophagy.

Structural, functional and molecular dynamics analysis of cathepsin B gene SNPs associated with tropical calcific pancreatitis, a rare disease of tropics.

The paper analyzes structural and functional effects of CTSB SNVs in tropical calcific pancreatitis using molecular dynamics and simulation tools.

Genetic analysis of the STIM1 gene in chronic pancreatitis

The paper identifies rare STIM1 coding variants enriched in chronic pancreatitis patients compared to controls, suggesting a potential genetic association.