Katja Steiger

This study shows that NIK stabilization causes chronic pancreatitis and pancreatic lipomatosis via RelB-dependent non-canonical NF-κB signaling.

This study identifies LOY as a driver of aggressive PDAC through epigenetic reprogramming, linking it to EMT and metastasis, and highlights its clinical relevance as a biomarker.

This study uses pan-cancer phosphoproteomics to identify therapeutic targets and improve precision oncology by analyzing 1,998 tumor samples and developing new scores for kinase activity and immune response.

This study shows that different colorectal cancer genotypes create distinct microbial ecosystems and that microbiota dependence decreases as tumors progress.

This study uses an in ovo model to show that the CAM platform supports tumor-stroma coevolution in pancreatic cancer, preserving patient-specific features and enabling functional analysis of stromal interactions.

This study examines how bile acid modulation affects colonic epithelial responses in mice and humans, finding altered cell populations and gene expression associated with DCA exposure.

This study integrates single-cell spatial transcriptomics with bulk and single-cell RNA sequencing to reveal the molecular heterogeneity and mechanisms of atherosclerotic carotid artery plaques.

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

The paper shows that Treg cells use IFNγ and IL-10 to promote intestinal stem cell growth and repair after injury.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

This study shows that IBD susceptibility increases the risk of ATF6-driven tumorigenesis in a murine model.

InSituPy provides a framework for analyzing single-cell spatial transcriptomics data alongside histology and metadata across multiple samples.

The paper profiles proteomes from 1,220 FFPE tumors across six cancers, identifies a new normalization method, and reports a comprehensive pan-cancer proteome resource.

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

This study identifies RNF43 mutations as a driver of colitis-associated cancer by showing their role in promoting inflammation and dysbiosis in mouse models and human patients.

This study evaluates three PDAC molecular signatures across eight datasets, finding inconsistent subtyping and low classification accuracy, suggesting technical biases and the need for multi-omic approaches.

The paper reports germline recombination in Ptf1a-driven Cre mouse lines when the Cre allele is paternally transmitted, emphasizing the need for genotyping and maternal transmission to avoid unintended recombination.

The paper uses single nucleus and in situ RNA sequencing to create a comprehensive atlas of human pancreas cells, revealing cell topographies and differences between adult and neonatal pancreata.

This paper develops a machine learning model to predict molecular subtypes of PDAC from radiomic features, showing differential chemotherapy response based on subtype.