Carmine Carbone

This study identifies a diet-imprinted macrophage-tumor circuit driven by the CAMP-P2RX7 axis that promotes pancreatic cancer initiation, plasticity, and metastasis.

This study identifies MAPK signalling as defining fibroblast subtypes in pancreatic cancer, linking MAPKhigh CAFs to poor prognosis and immune evasion.

This study shows that acute pancreatitis induces epigenetic changes in acinar cells, leading to long-term tumor predisposition through altered cell states and plasticity.