Extracellular vesicles in disease

This study examines how ischemia and inflammation affect plasma-derived extracellular vesicle characteristics and function in brain tissue, finding that both types of EVs induce pro-inflammatory cytokine expression without distinct glial reactivity.

This study compares extracellular vesicles from three odontogenic cell types, finding donor-specific differences and highlighting their therapeutic potential.

The paper identifies mutant proteins in urinary extracellular vesicles using a proteogenomics pipeline and shows their correlation with bladder cancer tumor burden, suggesting a non-invasive liquid biopsy method.

This study demonstrates that the Hemopurifier device removes 98.5% of platelet microparticles from healthy human plasma in a 4-hour session.

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

The paper uses fluorescence microscopy to show that plant extracellular vesicles (EVs) are heterogeneous, with distinct markers like TET8 and PEN1 labeling different subpopulations.

This paper introduces BDEVS, a platform for high-throughput, multiplexed, and ultra-sensitive profiling of individual extracellular vesicles in plasma, demonstrating a 100x improvement in detecting EV subpopulations.

This study identifies critical parameters for lipid-anchored protein loading into extracellular vesicles and demonstrates efficient intracellular delivery.

This study identifies a novel pathway involving CD24, aSMase, PI3K/mTORC2/ROCK/actin that regulates bioactive ectosome formation in B lymphocytes.

This study shows that naked extracellular RNA can be pro-inflammatory and functionally active in immune cells when ribonuclease inhibitors are present, challenging the need for RNA encapsulation.

This study shows that vaginal bacteria-derived extracellular vesicles can diffuse through cervicovaginal mucus and interact with reproductive tract tissues, potentially contributing to disease and offering therapeutic potential.

The paper identifies host proteins in human semen-derived extracellular vesicles that interact with HIV Tat and NF-κB, suggesting they may repress HIV by targeting transcription factors.

This study shows that exercise-induced extracellular vesicles reduce colon cancer cell viability and induce apoptosis, with higher intensity exercise producing stronger effects.

This study isolates and analyzes brain-derived extracellular vesicles from umbilical cord blood to detect non-infectious neuroinflammation and neonatal iron deficiency in infants.

This study identifies functional differences between subpopulations of endogenous tissue-derived extracellular vesicles in skeletal muscle, showing distinct biological effects and potential applications in biomarker discovery and therapy.

miRTalk infers EV-derived miRNA-mediated cell-cell communication from scRNA-seq data, showing high accuracy in simulated and real datasets.

The paper validates EV isolation from multiple biofluids using orthogonal methods but finds L1CAM does not reliably enrich for neuron-derived EVs.

This study quantifies membrane vesicles in freshwater ecosystems using flow cytometry and interferometric microscopy, finding agreement in nanoparticle abundance and suggesting associations with virus particles or dense compounds.

This study shows light-intensity exercise increases miR-200a-3p in muscle exosomes and plasma, improving memory in T2DM mice, and mimicking exercise effects through miR-200a-3p treatment.

This paper describes a method to isolate gut-derived extracellular vesicles (ColEVs) and shows that purified ColEVs can activate the HIV LTR promoter.

This study shows that manipulating the extracellular vesicle biogenesis pathway in male Drosophila somatic cells leads to sex-specific phenotypic changes in offspring.

The paper characterizes exosomal RNA cargo in pleural mesothelioma, identifies potential biomarkers, and explores their role in cell communication and prognosis.

The paper identifies cargo proteins associated with polycystin EVs in C. elegans using a modular proximity labeling approach, revealing their role in EV subtype specificity.

This study shows Yersinia pestis inhibits neutrophil extracellular vesicle production, reducing antimicrobial cargo and inflammatory properties.

This study investigates how extracellular vesicles adhere to different surfaces and shows that borosilicate glass coverslips can effectively immobilize EVs for imaging techniques.

This study shows that maternal extracellular vesicles from COVID-19 pregnancies alter trophoblast function, contributing to placental dysfunction.

This study shows that milk-derived extracellular vesicles reduce NF-κB pathway and NLRP3 inflammasome activation in neonatal rats exposed to maternal high fat diet.

This paper develops ApoFilter, an aptamer-based method to remove lipoproteins from blood, enabling ultra-pure extracellular vesicle isolation with high efficiency and minimal EV loss.