Maureen M. Barr

This study identifies SCM-1/SCAMP as a key factor maintaining microdomain boundaries in the endosomal system, ensuring proper cargo sorting and preventing microdomain overlap.

This paper uses a C. elegans model to functionally classify an ADPKD variant, showing it acts recessively by disrupting polycystin complex function.

This study shows that the ECM gene mec-9 affects sensory cilia function and EV shedding in C. elegans through non-autonomous mechanisms.

The paper identifies cargo proteins associated with polycystin EVs in C. elegans using a modular proximity labeling approach, revealing their role in EV subtype specificity.

This study identifies SID-2 as an extracellular vesicle protein in parasitic nematodes that does not function in environmental RNAi, suggesting a shift in its ancestral role.

This study identifies ciliary intrinsic mechanisms that regulate dynamic extracellular vesicle release from sensory neurons in C. elegans, showing that KLP-6 and TTM-5 are required for sustained release.

This study shows NEKL-4 regulates ciliary stability and mitochondrial health in C. elegans ciliated neurons through kinesin activation and mitochondrial homeostasis.

The paper identifies cell-specific tubulin and IFT cargo proteins that generate a non-canonical transition zone in cilia through microtubule loss and reorganization.

The paper identifies genes that regulate microtubule glutamylation and ciliary integrity in C. elegans, showing their role in preventing neuronal ciliary degeneration.

The paper investigates the role of extracellular matrix (ECM) in regulating cilia and EVs in C. elegans, linking ECM dysfunction to ciliopathies.