Cell Adhesion Molecules Research

This study shows MFGE8 inhibits insulin signaling by promoting PTP1B binding to and dephosphorylation of IR{beta}, reducing glucose uptake, and identifies a correlation between serum MFGE8 levels and insulin resistance in humans.

This study identifies how the monoclonal antibody 66E8 stabilizes E-cadherin adhesion by stabilizing the strand-swap dimer conformation through electrostatic interactions.

This study shows ICAM-1 nanoclusters control hepatic epithelial cell polarity through actomyosin regulation, independent of leukocyte adhesion.

This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.

The paper investigates how collagen and DDR-2 signaling coordinate integrin adhesion between adjacent tissues in C. elegans.

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

This study identifies nidogen-2 as a physical and genetic interaction partner of hemicentin-1, showing their cooperative role in basement membrane integrity.

The paper identifies a surface on PAT-4 that interacts with UNC-112 through genetic analysis in C. elegans.

This study shows that integrin function is required for maintaining cellular organisation and shape during Drosophila egg chamber morphogenesis, but not for pre-follicle cell polarity.

The paper determines the structures of engineered knottins 2.5F and 2.5D in complex with integrin αVβ3 and reveals structural mechanisms underlying their differential binding to αVβ3 and α5β1.

The paper uses evolutionary rate covariation analysis to identify genes coevolving with Drosophila E-cadherin, revealing novel regulators of cell adhesion and actin dynamics.

This paper investigates the role of Nidogen/entactin in basement membrane assembly and morphogenesis in Drosophila, showing tissue-specific requirements and functional domains of Ndg.

The paper shows integrin signaling suppresses filopodia in Drosophila myotubes during muscle-tendon attachment, enabling actin machinery to form strong attachments.

The paper identifies new functions of integrin-associated proteins in Drosophila myotendinous junctions, revealing their roles in regulating adhesion and mechanotransduction.