Cell Adhesion Molecules Research

Transmembrane-domain-driven heterodimer assembly licenses integrin head-domain folding in the endoplasmic reticulum

This study shows that transmembrane domain interactions in integrin β1-subunit are essential for proper folding and surface expression, with mutations disrupting these interactions causing functional impairments and embryonic lethality.

FAK Dependent Focal Adhesion Remodeling Drives Arsenical Vesicant Induced Skin Injury

This study shows that FAK activation drives PAO-induced skin injury by disrupting focal adhesions, and inhibiting FAK protects against vesicant-induced damage.

Integrin α3β1 is required for alveolar-capillary barrier formation through regulation of epithelial differentiation

This study shows that integrin α3β1 is essential for alveolar-capillary barrier formation by regulating epithelial differentiation during lung development.

Terminal Modification Reprograms Supramolecular Organization of Integrin Ligand Assemblies to Shape Cell Migration

This study shows that terminal modifications of integrin ligands can reprogram their supramolecular organization and function, affecting cell migration without altering the sequence.

LNA043 and ANGPTL3 Interactions with Integrin α5β1 and Fibronectin Drive Distinct Stromal and Immune Responses

The paper investigates how LNA043 and ANGPTL3 interact with integrin α5β1 and fibronectin to drive distinct stromal and immune responses in osteoarthritis.

Uncovering the role of laminin(lama5) in maintenance of epithelial identity and polarity in bilayer zebrafish epidermis during development

This study investigates the role of laminin 5 in maintaining epithelial polarity and identity in zebrafish epidermis, finding that its loss leads to mesenchymal traits and altered cell behavior.

α-Parvin regulation of cell re-arrangement is critical for ureteric bud branching morphogenesis

This study shows that α-parvin regulates cell rearrangements during ureteric bud branching by inhibiting cell adhesion and actin polymerization.

Structural Basis for MCAM Mediated Inhibition of Laminin Dependent Cell Migration

This study determines the structural basis of MCAM-mediated inhibition of laminin-dependent cell migration by showing MCAM and integrin compete for a shared laminin interface.

Structural basis for tetraspanin-dependent surface export and adhesive function of integrin α3β1

The paper reports the cryoEM structure of the ITG3β1-CD151 complex and shows CD151 promotes ITG3β1 surface export, explaining the epidermolysis bullosa phenotype.

Engineering Stapled Peptide Inhibitors Reveals Design Principles for Targeting Talin-Induced Integrin Activation

The paper designs stapled peptides targeting talin-induced integrin activation, showing improved binding and cell uptake in optimized versions.

Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A

This study compares two anti-α5β1 antibodies, showing they share ligand-blocking mechanisms but differ in conformational modulation, with implications for therapeutic design.

Composition-controlled artificial collagen shows opposing roles of collagen-binding integrins and discoidin domain receptors in neuronal differentiation of PC12 cells

This study uses artificial collagen to show that integrins and DDRs have opposing roles in PC12 cell differentiation.

Integrin diversity enables dynamic adhesion control in a homeostatic epithelium

The paper shows that integrin diversity in Drosophila midgut epithelia enables dynamic adhesion control, with enterocytes competing for basement membrane adhesion and being extruded when less adhesive.

Phage Display-Derived Cyclic Peptides as Ligand-Specific Modulators for β2-Integrin Receptors

This study develops cyclic peptides from phage display to modulate β2-integrin receptors, showing they inhibit ligand binding to I-domains and affect cell adhesion.

δ-Catenins couple cadherin adhesions to phospholipid-rich membrane domains

This study identifies two distinct mechanisms by which Pkp4, a δ-catenin, is recruited to adherens junctions: one via cadherin binding and another via phospholipid-rich membrane domains.

Systematic functional genetic analysis of cell-substrate adhesion

This study identifies gene targets involved in cell-substrate adhesion through functional genetic analyses in human cells, revealing dynamic requirements and novel regulators.

SNED1 fibrillar assembly in the extracellular matrix requires fibronectin and collagen I

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation

This study presents the high-resolution cryo-EM structure of integrin αIIbβ3 bound to an anti-HPA-1a antibody, revealing how it blocks integrin activation and platelet aggregation.

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity

The paper identifies a signaling axis involving SorLA, integrin, and HER2/HER3 that regulates apicobasal polarity in mucinous colorectal adenocarcinoma and shows its therapeutic relevance.

Integrins and tetraspanins mediate CD36-actin coupling and regulate CD36 organization and signaling

This study identifies integrins and tetraspanins as mediators of CD36-actin coupling, showing their role in CD36 organization and signaling in vascular endothelial cells.

Integrin-identity shapes and mechanotemporally encodes the fibroblast transcriptome

This study shows integrin-identity shapes fibroblast transcriptomes under mechanical confinement, with distinct gene clusters and states depending on integrin class and confinement duration.

Patterned integrin-laminin adhesion coordinates epithelial collective cell migration

The paper shows integrins 3 and 6, along with laminin 5, coordinate epithelial collective migration in zebrafish pLLP by maintaining basement membrane integrity and regulating protrusive activity.

Numerical study of spatial and temporal dynamics of integrin clustering during early cell adhesion

This study uses a hybrid model to simulate integrin clustering during early cell adhesion, showing that membrane deformation and integrin-ligand binding determine cluster spatial distribution.

Epithelial eversion, a collective rearrangement from apical-in to apical-out polarity, is initiated by α6β4 integrins and sustained by increased cell proliferation and anchorage-independence

This study identifies α6β4 integrins as initiators of epithelial eversion and shows that increased cell proliferation and anchorage-independence sustain apical-out polarity.

Sidekick2 facilitates multiciliated cell penetration through multicellular adherens junctions

This study shows Sidekick2 facilitates multiciliated cell penetration through multicellular adherens junctions during radial intercalation in Xenopus laevis.

Adhesion-derived condensates control component availability to regulate adhesion dynamics

This study shows that TNS1 phase separation regulates adhesion dynamics by controlling the availability of inactive adhesion proteins through phosphorylation-dependent condensate formation.

Oncostatin M cytokine promotes breast cancer progression by remodelling the extracellular matrix and activating integrin signalling in cancer cells

Mindin mediated αM-Integrin endocytosis activates STAT3 to maintain keratinocyte stemness

The paper shows that Mindin-mediated αM-Integrin endocytosis activates STAT3 to maintain keratinocyte stemness.

The Lipid-binding PX Domain of RRC-1 (ARHGAP32/33) is Required for Optimal Assembly and Function of Integrin Adhesion Complexes at the Muscle Cell Boundary in C. elegans

The paper shows that the PX domain of RRC-1 is necessary for its localization to muscle cell boundaries and for proper integrin adhesion complex assembly and function in C. elegans.

Talin-1 determines the direction of primary mouse neutrophils migrating in vivo

This study uses EGFP-talin1 knock-in mice to show talin-1 dynamics during neutrophil migration in vivo, revealing its polarization during directional movement.