Advanced Drug Delivery Systems

This study develops a photocrosslinked hyaluronic acid hydrogel for nasal drug delivery, showing improved mucoadhesion and stability compared to uncrosslinked versions.

The paper develops a bioresorbable implant system for long-term contraception that improves drug delivery efficiency and reduces the need for surgical intervention.

This study evaluates a ciprofloxacin-loaded micellar bioconjugate carrier for eradicating bacterial biofilms, showing enhanced antibiofilm activity under acidic conditions.

This study shows that intranasal administration of isradipine achieves higher brain concentrations than plasma, enabling targeted Cav1 Ca2+ channel inhibition with fewer peripheral side effects.

This paper presents a novel oral insulin tablet formulation using two excipients that is heat stable, protects insulin from degradation, and enables sustained glucose control without cold storage requirements.

This paper develops a prodrug system for targeted colonic delivery of budesonide using gut commensals, showing improved drug localization and reduced systemic side effects.

This paper develops rapid in situ forming PEG hydrogels for mucosal drug delivery that degrade naturally and adhere to mucus-coated tissues.

This paper develops pectin-coated nanoparticles that deliver an inflammation-resolving peptide to the colon post-surgery, improving anastomotic healing in a murine model of colitis.

This study develops a once-monthly dosing form of semaglutide using hydrogel microspheres, showing equivalent weight loss to daily dosing in mice and simulating human efficacy.

This paper develops chitosan nanocapsules with Alstonia boonei extract and shows they prevent dexamethasone-induced immunosuppression in rats at certain doses.

This paper develops acrylic acid-modified PEG-DA microparticles for sustained IGF-1 release, showing enhanced loading efficiency and biological activity in neuronal assays.

This study optimizes PLGA microparticle fabrication by adjusting polymer content and cleaning steps, finding lower PLGA content improves yield, encapsulation, and controlled drug release.

This study evaluates teff grain resistant starch as a film coating material for colon-targeted drug delivery of metronidazole, finding optimal ratios and thicknesses for controlled release in the colon.

This paper develops hydrogel microsphere-drug conjugates for long-acting intra-tumoral therapy, showing improved efficacy and reduced toxicity compared to systemic delivery.

This paper develops sustained-release nor-LAAM-loaded PLGA microparticles for OUD treatment, showing prolonged drug release and reduced fentanyl choice and withdrawal in rats.

This paper develops aripiprazole-loaded thiolated arabinoxylan nanoparticles to improve schizophrenia treatment, showing sustained release and safety in vitro and in vivo.

This paper develops a synthetic mucus barrier array platform for high-throughput screening of nanoparticle formulations to improve mucosal drug delivery.

This paper introduces a biomimetic lipid-polymer composite membrane model to study drug permeability through the cornea, showing it matches excised corneal permeation data.

This study evaluates a novel maxillofacial drug delivery technique for targeting the retina, optic nerve, and brain via the glymphatic system, showing it is effective compared to traditional methods.

This study develops a solid lipid nanoparticle formulation for efficient delivery of hydrophilic drugs to retinal cells, showing improved encapsulation efficiency and cellular uptake.

This study demonstrates a novel technique and device for controlled and continuous drug delivery into the brain without surgical intervention, showing increased drug levels in brain regions and ex vivo models.

The paper synthesizes and characterizes a pH-sensitive nanocomposite for drug delivery, showing high drug release in intestinal conditions.