Spinal Cord Injury Research

This study shows that High-Low training improves respiratory function and reduces anxiety-like behaviors in a rodent model of chronic spinal cord injury.

Cervical repetitive magnetic stimulation improves ventilatory recovery after spinal cord injury by enhancing diaphragm activity and reducing inflammation.

This study shows that cervical spinal cord injury increases phosphorylated tau without changing total tau levels, with effects extending beyond the injury site.

This study identifies Hapln1-HA signaling as a pro-regenerative mechanism in zebrafish spinal cord injury by enhancing progenitor cell proliferation and repair.

This paper shows that rehabilitation after spinal cord injury promotes specific reorganization of corticospinal pathways in medullary motor nuclei, improving motor function.

The paper uses proteomic analysis to identify acrolein-induced changes in rat spinal cord injury, revealing shared pathways in complement and coagulation cascades.

This study shows that drug-free polymeric nanoparticles improve locomotor recovery after spinal cord injury in both sexes through sex-specific immune mechanisms.

This study quantifies persistent postural and motor deficits after spinal cord injury in mice using unbiased, high-speed video tracking and machine learning.

This study identifies altered inhibitory-excitatory balance as a key mechanism causing motoneuron dysfunction in incomplete spinal cord injury.

This study compares the neuroprotective effects of minocycline and bone marrow mononuclear cells after spinal cord injury in rats, showing they target different aspects of secondary injury.

This study investigates the effects of endogenous and exogenous ketosis on spinal cord injury in rats, finding that ketosis enhances anti-inflammatory and antioxidant responses when combined with methylprednisolone.

The paper characterizes mitochondrial dysfunction at different time points after spinal cord injury in male pigs to understand its temporal progression and potential therapeutic targets.

The paper examines whether gut microbiota changes after spinal cord injury affect axon regeneration in lampreys, finding no impact on spontaneous regeneration.

This study combines biomaterial scaffolds and microtubule stabilizers to improve axon regeneration and motor recovery in chronic spinal cord injury.

This study shows that DLK inhibition after spinal cord injury improves neuroprotection in female mice but worsens recovery and increases lesion size in males.

This study shows that reprogramming NG2 glia with SOX2 improves bladder function in a mouse model of spinal cord injury by promoting neurogenesis and reducing glial scarring.

The paper develops a computational model to simulate tSCS effects on motor function, finding that somatosensory afferents have lower thresholds than motor efferents, and that anode placement and waveform type influence recruitment patterns.

This study compares neuroimmune responses in two cervical spinal cord injury models in mice, finding distinct inflammatory and repair profiles between hemisection and hemi-contusion injuries.

This study shows curcumin promotes myelin repair after spinal cord injury by selectively regulating CLASP2 phosphorylation, enhancing cytoskeletal organization and remyelination.

This paper develops a biologically constrained spiking neural network to model neuromodulation effects on locomotor recovery after spinal cord injury, finding that reducing GABAergic inhibition improves movement coordination.

This study shows that combining botulinum neurotoxin type A with electrical muscle stimulation improves motor function and reduces neuropathic pain in chronic spinal cord injury.

This study shows that early post-injury changes in mouse respiration and motor activity can predict future pain-related outcomes after spinal cord injury.

This study shows that biceps brachii stimulation can enhance phrenic motor output in rats with cervical spinal cord injuries, suggesting a spinal mechanism for breathing recovery.

This study shows that blocking ADGRG1 allows astrocytes to enter the fibrotic matrix, reducing scar size and improving motor recovery after CNS injury.

This study identifies early vascular leakage beyond the injury epicenter as a driver of secondary pathology after SCI and shows that stabilizing the blood-spinal cord barrier improves recovery.

This study identifies a hypothalamic-pontine-spinal pathway that promotes locomotion and functional recovery after spinal cord injury in mice through optogenetic manipulation and deep brain stimulation.

This study shows that olfactory ensheathing cells from previously injured animals have reduced therapeutic potential in spinal cord injury treatment compared to healthy donor cells.

This study shows that poly-L-ornithine-coated plant scaffolds improve motor recovery and neural repair in rats with spinal cord injury.

This study uses whole-brain autoradiographic mapping to show changes in glucose metabolism in mice following spinal cord injury, revealing both decreased and increased metabolic activity in different brain regions.