Spinal Cord Injury Research

This study shows that mature neutrophils promote long-term functional recovery after spinal cord injury, with effects differing by sex.

This study investigates how neuronal activity protects spinal interneurons from degeneration after corticospinal injury and shows that rescuing these neurons restores motor function.

This study investigates the mechanisms of hyperreflexia after corticospinal tract lesion, finding that it is linked to 1A afferent circuit changes rather than KCC2 hyperexcitability.

This paper introduces a novel lower limb pointing task to assess motor strategies and proprioceptive impairments in individuals with incomplete spinal cord injury.

This study shows that spinal cord cell transplants can reverse cognitive decline and brain inflammation caused by spinal cord injury in mice.

The paper uses a computational model to simulate and predict changes in locomotion phase durations after a spinal hemisection in cats, comparing results with experimental data.

This study introduces a PET tracer, [18F]3F4AP, to image demyelinated axons in spinal cord injuries and shows its ability to detect injury and monitor changes in animal models and humans.

This study shows that low-level spinal cord injury increases lung inflammation and immune response after LPS exposure, with heightened macrophage activity.

This study shows that increased interstitial fluid pressure and flow after spinal cord injury contribute to neural degeneration.

This paper develops D-hydrogels that manipulate mechanotransduction to promote neurogenesis and immunomodulation in spinal cord injury models.

This paper presents 3D printed scaffolds with microtunnels for spinal cord injury treatment in rats, showing improved motor function and axonal regeneration.

This study shows that stimulating the ipsilateral motor cortex in rats with spinal cord injury can restore bilateral limb movement and postural control.

This study shows that sustained inflammation in chronic spinal cord injury, mediated by macrophages and microglia, inhibits axon regeneration, and that reducing inflammation can increase axon density in specific populations.

This study shows treadmill training enhances corticospinal tract rewiring and improves motor recovery in SCI mice, with motivation influencing specific kinematic outcomes.

This study examines the impact of mesenchymal stem cell-derived extracellular vesicles encapsulated in fibrin matrix on cytokine levels in a rat spinal cord injury model, showing dose-dependent modulation of inflammatory markers.

This study applies pharmacological agents immediately after spinal trauma in rats to identify treatments that reduce injury potentials and restore reflexes, finding TRPV4 antagonism and GABAA receptor modulation are effective.

This study examines changes in reflex pathways from forelimb cutaneous afferents after thoracic spinal cord injuries in cats, showing reduced hindlimb reflex responses and altered coordination during locomotion.

This paper introduces two marker-less kinematic analysis systems for assessing mouse locomotor function after spinal cord injury, validated against traditional methods and showing high sensitivity and accuracy.

This study identifies Sirt1 as an epigenetic regulator of spinal cord regeneration in zebrafish by modulating the HIPPO pathway through interaction with Dnmt1.

This study investigates the timed administration of glibenclamide and diazoxide to improve locomotor and sensory function after spinal cord injury in rats.

This study investigates how kilohertz-frequency waveforms in transcutaneous spinal cord stimulation affect fiber recruitment, showing they increase response thresholds and bias recruitment toward efferent fibers.

This study tests 4-AP's effect on SCI recovery in zebrafish, finding 10 M 4-AP improves swimming distance by 40% without axon regeneration.

This study investigates the immediate effects of spinal cord injury in an in vitro model, revealing chloride ion-dependent depolarizations and transient cortical glial changes.

The paper analyzes single-cell and spatial transcriptomic data to identify microglial cell changes in spinal cord injury and proposes strategies to enhance recovery through Trem2 inhibition and iPSC-derived microglial cell transplantation.

This study evaluates the synergistic effects of Roflumilast combined with Levetiracetam or Adipose Stem Cell secretome after spinal cord injury, finding no improvement in functional outcomes compared to single treatments.

This study shows that combining genetic deletion of RhoA and Pten with neuronal stimulation enhances axon sprouting and partial motor recovery after cervical spinal cord injury.