Telomeres, Telomerase, and Senescence

P-selectin-targeted fucoidan nanoparticles carrying Navitoclax or dBET6 deplete a senescent-like, lipid-associated macrophage subset, reverse mouse liver and lung fibrosis with less toxicity, and restore checkpoint therapy response in fibrotic tumors.

Merging CellAge, GenAge, SenMayo and Reactome senescence genes onto Ensembl IDs yields 1,250 provenance-tracked genes, most also annotated with mouse/zebrafish orthologs, tissue expression and STRING interactions.

Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.