Telomeres, Telomerase, and Senescence

Impaired synthesis of both telomere strands and adaptive TERT reduction in RTEL1 ATPase-dead cells

This study shows RTEL1 ATPase activity is essential for both telomere strand synthesis and TERT regulation, with reduced TERT providing an adaptive survival mechanism in RTEL1-defective cells.

Targeting MK2-Driven Stromal Senescence Sensitizes Breast Cancer Bone Metastasis to Immunotherapy

This study identifies senescent cancer-associated fibroblasts (senCAFs) driven by MK2 that promote immunosuppression in bone metastases and shows that combining MK2 inhibition with OX40 agonists enhances immunotherapy efficacy.

Long-read sequencing reveals telomere inheritance patterns from human trios

The paper uses long-read sequencing to analyze telomere inheritance patterns in human trios, finding parent-of-origin effects and heritable influences on telomere length.

Dual Role of Cx43 in Enhancing CDK4/6 Inhibitor Response and Promoting the Elimination of Therapy-Induced Senescent Tumor Cells

This paper identifies Cx43 as a target that enhances CDK4/6 inhibitor efficacy and promotes elimination of therapy-induced senescent tumor cells through senolytic agents.

Identification of an Endothelial Senotype Predicted by Ion Channel Expression in Aged Murine Perigonadal Adipose Tissue

The paper identifies age-dependent senescent endothelial cells in adipose tissue using snRNA-Seq and finds ion channel genes as predictive biomarkers.

Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition

This study shows that standard therapies for paediatric BRAF-V600E glioma induce senescence, which can be targeted by BCL-xL inhibitors to prevent tumour regrowth.

Spontaneous replication fork collapse regulates telomere length homeostasis in wild type cells

The paper shows that telomerase elongates a second substrate formed by spontaneous replication fork collapse in budding yeast, significantly contributing to telomere length homeostasis.

CST-Polα/primase, backed up by Rif1, protects telomeric ss-dsDNA junctions from damage recognition and resection

The paper investigates the role of CST-PP complex in protecting telomeric ss-dsDNA junctions from damage and resection in yeast, showing that Rif1 supports this protection.

Rewired mRNA homeostasis enforces cell-size associated senescence

This study shows that excess cell size drives senescence by altering mRNA homeostasis and reorganizing the genome, leading to the secretory phenotype and cell cycle arrest.

Telomere dynamics parameters inferred from mathematical modeling of telomere length distribution

The paper develops a mathematical model to infer telomere dynamics parameters from telomere length distributions in yeast using long-read sequencing data.

Multidimensional telomere diversity and inheritance at individual and population scales

This paper introduces TeloXplorer, a framework for analyzing telomere features in long-read data, showing how telomere diversity is inherited across species and populations.

Escape from replicative crisis and immortalization precedes complex genome evolution

The paper shows that escaping replicative crisis and achieving immortality precedes complex genome evolution in cancer cells.

The ammonia-senescence ratchet drives an adaptation-senescence-ammonioptosis transition in liver cancer

This study identifies an ammonia-senescence ratchet mechanism that drives tumor cells from metabolic adaptation to senescence and ultimately to ammonioptosis.

TRF2 mediates force-resistant bridging of distal telomeric DNA repeats

This study shows TRF2 mediates force-resistant tethering of telomeric DNA repeats, which may be a step in T-loop formation.

Senotherapeutic potential against xeroderma pigmentosum

This study identifies senomorphic and senolytic agents that counteract UV-induced senescence in XP-derived melanocytes, reducing SASP gene expression and related pathway activation.

Identification of senescence-associated drivers of tumour growth and progression using a novel microarray platform

This study identifies SASP factors that drive tumorigenesis in breast and lung cancer cells using a microarray platform and validates their role in growth and survival.

A two-step organoid screen identifies transient p53 activation as a senolytic strategy for radiation-induced salivary gland dysfunction

The paper identifies Nutlin3a as a senolytic compound that reduces radiation-induced salivary gland dysfunction by transiently activating p53 in a two-step organoid screening approach.

Single-stranded telomeric repeats segregate into spatial compartments within ALT-associated PML bodies

The paper uses super-resolution microscopy to show that single-stranded telomeric repeats are spatially segregated within ALT-associated PML bodies.

Thiomorpholino antisense oligonucleotides inhibit telomerase and limit cancer cell proliferation

This study evaluates thiomorpholino antisense oligonucleotides (TMOs) as telomerase inhibitors, showing they reduce telomerase activity and limit cancer cell proliferation.

UHRF1 Overexpression Generates Distinct Senescent States with Different Tp53 Dependencies

This study shows UHRF1 overexpression in zebrafish hepatocytes leads to diverse senescent states with different Tp53 dependencies and responses to senolytic drugs.

The p53-p21-Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD.

Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries

This study identifies GPR81 loss as a driver of vascular senescence and shows that its activation can reverse age-related metabolic dysfunction in arteries.

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

P-selectin-targeted fucoidan nanoparticles carrying Navitoclax or dBET6 deplete a senescent-like, lipid-associated macrophage subset, reverse mouse liver and lung fibrosis with less toxicity, and restore checkpoint therapy response in fibrotic tumors.

Metabolic-Epigenetic Coupling in Cellular Senescence: In Silico Cristae Remodeling Depletes Alpha-Ketoglutarate to Drive KDM4/6 Inhibition and SASP Amplification

The paper develops a computational systems biology framework to model metabolic-epigenetic coupling in cellular senescence, showing how mitochondrial remodeling and alpha-ketoglutarate depletion inhibit KDM4/KDM6 and amplify SASP.

Mitochondrial dysfunction and impaired osteogenic capacity define stress-induced osteoblast senescence

This study identifies mitochondrial dysfunction and impaired osteogenic capacity as key features of stress-induced osteoblast senescence using in vitro models and transcriptomic analysis.

Genotoxic and metabolic stress drive divergent senescence programs in human microglia

This study shows that chronic genotoxic and metabolic stress induce distinct yet overlapping senescence programs in human microglia, characterized by morphological changes, mitochondrial remodelling, and inflammatory activation.

Telomere length of both parents contributes to heritable POT1 cancer-predisposition syndrome

The paper investigates how POT1 mutations affect telomere inheritance and cancer risk by analyzing telomere length in families with POT1 mutations.

SenSASP: A Unified, Multi-Layer Database of Senescence and SASP Genes

Merging CellAge, GenAge, SenMayo and Reactome senescence genes onto Ensembl IDs yields 1,250 provenance-tracked genes, most also annotated with mouse/zebrafish orthologs, tissue expression and STRING interactions.

Salvianolic acids are natural senolytics and increase lifespan in old age

This study identifies salvianolic acids as natural senolytics that enhance lifespan and healthspan in aged mice by targeting senescent cells through redox modulation and inducing apoptosis and ferroptosis.

Sacituzumab Govitecan as an Effective Strategy for Sensitizing Chemoresistant HNSCC Cells to Senolytic Intervention

This study shows that combining sacituzumab govitecan with the senolytic ABT-263 effectively overcomes chemoresistance in HNSCC by targeting senescent cells.