Acute Lymphoblastic Leukemia research

The paper identifies a distinct developmental state in KMT2A-rearranged infant B-cell acute lymphoblastic leukemia using single-cell transcriptome analysis.

The paper identifies high-risk factors and actionable targets in T-ALL through integrated genomic and transcriptomic analyses of 165 patients, finding RAS pathway and PTEN mutations as poor survival factors and potential therapeutic targets.

This study identifies five novel genetic loci associated with childhood acute lymphoblastic leukemia through a trans-ethnic meta-analysis across four ethnic groups.

This study identifies genetic variants influencing blood cell traits linked to increased susceptibility to childhood acute lymphoblastic leukemia.

ALLSorts classifies B-ALL samples into 18 subtypes and five meta-subtypes using RNA-Seq data with high accuracy.

The paper constructs a gene regulatory network for MLL-AF4 to reveal an indirect repression of CASP9 via RUNX1 as a mechanism of apoptosis resistance.

This study identifies NT5C2 germline variants affecting 6-MP metabolism in ALL patients, showing two independent variants influence TGN levels.

The paper identifies new therapeutic targets in CRLF2-overexpressing B-ALL by analyzing TF-gene regulatory interactions using network inference and experimental validation.

The paper identifies 3D genome alterations and enhancer hijacking mechanisms in T-lineage acute lymphoblastic leukemia (T-ALL) using integrated analyses of 18 patients and 4 controls.

This study uses linked-read whole genome sequencing to detect and phase structural aberrations in pediatric ALL with higher resolution than traditional methods.

This study identifies DPEP1 as a prognostic marker in adult B-cell acute lymphoblastic leukemia, showing its role in proliferation and survival through phosphCREB and p53 regulation.

The paper presents a comprehensive dataset of TLX1 positive ALL-SIL lymphoblasts and primary T-ALL leukemias using polyA[+] and total RNA sequencing, ATAC sequencing, and ChIP sequencing, validated for quality and biological relevance.

The paper identifies 20 key genes associated with dexamethasone resistance in acute lymphoblastic leukemia using differential expression and protein-protein interaction analysis.