Acute Lymphoblastic Leukemia research

Efficacy evaluation of glasedgib Sonic Hedgehog pathway inhibition with or without inotuzumab in B-ALL cells using a new co-culturing system model and a validated chemosensitivity assay

This study evaluates the efficacy of glasdegib and its combination with inotuzumab on B-ALL cells using a co-culturing system and chemosensitivity assay, showing varying responses based on SHH gene expression.

Single-Cell Sequencing in Pediatric Acute Leukemia: A Systematic Review of Biologic Insights and Translational Potential

This review evaluates single-cell sequencing findings in pediatric acute leukemia, highlighting insights into clonal evolution, chemoresistance, and immune dynamics, while noting limitations in study design and bias.

NHE1 sustains leukemia-propagating capacity and mitochondrial fitness in T-cell acute lymphoblastic leukemia

This study identifies NHE1 as a regulator of T-ALL leukemia-propagating activity and mitochondrial fitness, showing its therapeutic potential.

Glucocorticoid receptor activation reorganizes Wnt/LEF1 regulatory circuitry associated with therapeutic response in B-cell acute lymphoblastic leukemia

This study shows that GR activation reorganizes Wnt/LEF1 regulatory circuitry in B-ALL, influencing therapeutic response and resistance through chromatin state changes and gene regulation.

The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groups

The paper introduces ALLCatchR2, a machine learning classifier that identifies 20 T-ALL subtypes across multiple cohorts and age groups with high accuracy.

Single-Cell proteomics discerns patient-specific subpopulations in pediatric B-cell acute lymphoblastic leukemia

This study uses single-cell proteomics to identify patient-specific subpopulations in pediatric B-ALL, revealing relapse-prone phenotypes and potential for personalized therapy.

Sertraline and Carfilzomib Synergize to Target T-cell Malignancies with Serine/Glycine synthesis activity via Cholesterol Dysregulation, Cellular Stress and Immune Modulation

This paper shows that sertraline and carfilzomib work together to kill T-cell cancers by disrupting metabolism and changing the immune environment.

Single-cell multiomic mapping of genetic predisposition to childhood B-cell acute lymphoblastic leukemia

The paper uses single-cell multiomic analysis to identify genetic variants and regulatory disruptions linked to childhood B-cell acute lymphoblastic leukemia.

A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of inherited childhood leukemia predisposition

The paper uses CRISPR and single-cell transcriptomics to study how inherited variants in B-cell development contribute to childhood leukemia.

SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemia

This study identifies SOX11 as a driver of γδ-like T-cell acute lymphoblastic leukemia, showing its cooperation with LMO2 and MYCN to promote leukemogenesis.

clinTALL: machine learning-driven multimodal subtypeclassification and treatment outcome prediction in pediatric T-ALL

clinTALL is a deep learning framework that classifies pediatric T-ALL subtypes and predicts treatment outcomes using multimodal data, achieving high accuracy and concordance indices.

Unveiling Cerebrospinal Fluid Protein Biomarkers in Pediatric Acute Lymphoblastic Leukemia Using Proximity Extension Assay

This study identifies CSF protein biomarkers in pediatric ALL using proteomics and machine learning to characterize disease state and treatment response.

Single-cell multiomic profiling reveals lineage plasticity in pediatric B-lineage Acute Lymphoblastic Leukemia during the early phase of treatment

This study identifies lineage plasticity in pediatric B-lineage ALL during treatment by analyzing single-cell multiomic data from mmSW-positive and negative cases.

Leukemia Risk Factor ARID5B Coordinates HDAC-Mediated Transcriptional Repression

This study identifies ARID5B as a chromatin repressor that interacts with HDAC1/2 to repress B cell-specific genes, linking its germline variants to B-ALL risk.

The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia

This study identifies LIN28B as essential for fetal B-lymphopoiesis and KMT2A::AFF1 infant leukemia initiation, showing its role in promoting proliferation and leukemogenesis.

Molecular Characterization of T-Lineage Acute Lymphoblastic Leukemia by an Optimal-Transport Based Multi-Omics Integration Framework

OTTER improves T-ALL molecular characterization by integrating transcriptomic and genomic data using optimal transport, outperforming existing methods and identifying subtype-specific features.

Dynamics of the B-Cell gene regulatory network in differentiation determine evolutionary trajectories of childhood leukaemogenesis

This study models B-cell differentiation and leukaemogenesis using a logical framework to show how mutation timing and order affect disease progression in BCP-ALL.

ASS1 deficiency defines a therapeutic vulnerability in Philadelphia chromosome-positive acute lymphoblastic leukaemia

This study identifies ASS1 deficiency as a therapeutic target in Ph+ ALL, showing arginine deprivation induces apoptosis and overcomes TKI resistance.

RAG-mediated structural variation and its impact on relapse risk in acute lymphoblastic leukemia

The paper identifies RAG-mediated structural variants as a risk factor for relapse in pediatric B-ALL and T-ALL, independent of MRD status.

Reactivation of a TAL1 progenitor cell enhancer region by non-coding somatic variants in T-lineage acute lymphoblastic leukemia

The paper identifies non-coding somatic variants in TAL1 regulatory regions that reactivate enhancers normally active in hematopoietic stem cells in T-lineage acute lymphoblastic leukemia.

TCF3::HLF Orchestrates an Enhancer-Promoter Network with Activation of MEF2C to Promote Immature HSC gene Expression in Leukemia

This study identifies TCF3::HLF's role in rewiring the 3D genome to drive leukemia by regulating MEF2C and altering hematopoietic stem cell gene expression.

Mechanistic learning to predict and understand minimal residual disease

This paper develops a mechanistic learning framework to predict BCR::ABL1 fusion gene status and minimal residual disease using clinical data, finding that stem-like cell state is a strong predictor.

Mining single-cell transcriptomic data reveals distinct T-cell population in pediatric B-ALL and AML at diagnosis

The paper analyzes single-cell RNA sequencing data from pediatric B-ALL and AML patients to identify distinct T-cell subsets and their associations with clinical outcomes.

IntegrateALL: an end-to-end RNA-seq analysis pipeline for multilevel data extraction and interpretable subtype classification in B-precursor ALL

IntegrateALL is an RNA-seq pipeline that integrates expression-based subtyping, gene fusion detection, and virtual karyotyping to classify B-ALL with high accuracy.

B-cell precursor acute lymphoblastic leukaemia with IGH::CEBP rearrangement: what have we learnt over the years?

This paper reviews clinical and demographic features of IGH::CEBP-rearranged BCP-ALL cases and introduces new cases to encourage further study of this rare subtype.

The bone marrow microenvironment of RAS pathway mutant B-ALL is enriched for immunosuppressive regulatory T cells

This study identifies an immunosuppressive bone marrow microenvironment in RAS-mutant B-ALL, enriched for regulatory T cells, and suggests CTLA-4 blockade could enhance T-cell-engager efficacy.

Proteomic profiling reveals pleiotropic antimetabolite activity of triciribine in acute lymphoblastic leukemia

This study identifies triciribine's pleiotropic antimetabolite effects in ALL by showing its ADK-dependent activity and impact on multiple cellular pathways.

In vivo isogenic modelling unveils TP53-associated relapse trajectories in T-cell acute lymphoblastic leukemia

This study uses patient-derived xenografts to identify TP53-associated relapse mechanisms in T-ALL, showing relapse phenotypes linked to OXPHOS metabolism and MYC signaling.

Pseudogene co-expression networks reveal a robust prognostic signature of survival in pediatric B-ALL

The paper identifies a pseudogene co-expression signature that predicts survival in pediatric B-ALL using single-sample networks and LASSO feature selection.

Integrated multi-omic analysis reveals novel subtype-specific regulatory interactions in pediatric B-cell acute lymphoblastic leukemia

This study integrates transcriptomic, proteomic, and phosphoproteomic data from two pediatric B-ALL subtypes to identify subtype-specific regulatory interactions and potential therapeutic targets.