Roberto J. Botelho

This study shows that Rab7 activation improves lysosomal dynamics and mitophagic flux in iron overload, enhancing mitochondrial function and cell survival.

This study shows that mitophagy is essential for cell survival after ultrasound and microbubble treatment by mitigating mitochondrial damage and metabolic stress.

This study shows that lysosome pH is critical for LPS-induced lysosome tubulation in macrophages, as alkalinizing pH blocks tubulation while maintaining mTORC1 activity.

The paper shows PIKfyve regulates ER dynamics by balancing phosphoinositides at ER-lysosome contacts, affecting lysosome fission and ER morphology.

This study shows that LL-37 kills dividing E. coli by disrupting membranes during late division, while filamentation confers resistance, suggesting filamentation may aid UPEC survival during infections.

This study shows AMPK moves early endosomes to mitochondria via Gapex-5 to enhance iron delivery under nutrient scarcity.

This study identifies endomembrane depletion as a key factor in phagocytic capacity exhaustion in macrophages.

The paper shows that GATOR1 regulates GSK3β nuclear localization in response to amino acids, independent of mTORC1, and that this process supports cell survival under metabolic stress.