Lief E. Fenno

This paper introduces dHaloLife635, a chemigenetic fluorescence lifetime sensor for dopamine that shows selectivity and stability in live cells.

This paper develops ultrasound-responsive extracellular vesicles for targeted drug delivery to the nervous system, demonstrating controlled release and pain modulation in rats.

This study identifies Sst-Chodl inhibitory neurons that promote cortical synchrony and sleep by exerting long-range inhibition during low-arousal states.

The paper develops a knock-in Ntsr1-Flp mouse line for intersectional targeting of midbrain dopamine circuits and demonstrates its utility in distinguishing dopaminergic and non-dopaminergic neurons.

This study uses CRISPR/Cas9 to knock down Clock in mouse VTA dopamine neurons, revealing effects on sleep, behavior, and excitability linked to bipolar disorder.

The paper compares AAV serotype transduction rates in the hypothalamus of Arctic ground squirrels, finding AAV1 has higher transduction rates than AAV-DJ.

The paper identifies selective vulnerability of dopamine-glutamate neurons in aging as a mechanism weakening entorhinal dopamine signaling.

This study identifies how different subtypes of VTA glutamatergic neurons signal reward and aversion in distinct ways, highlighting unique roles in behavioral salience.

This paper develops a non-invasive optogenetics method using ultrasound-triggered nanotransducers to modulate Parkinsonian rats' neurons and improve movement dysfunction.

This study identifies monosynaptic inputs to VTA VGluT2+VGaT+ neurons in mice, revealing diverse brain-wide connections and distinct behavioral outcomes from lateral hypothalamus and superior colliculus inputs.

The paper identifies Ribosome-Associated Vesicles (RAVs) as dynamic platforms that facilitate activity-dependent local translation in neurons by transporting ribosomes to distal processes.

The paper shows that vmPFC Dyn neurons suppress defensive behaviors by releasing dynorphin in response to threats and promoting fear-related network states.

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

The paper identifies three genetic dopamine subtypes in the substantia nigra pars compacta, each with distinct functional responses to rewards, aversive stimuli, and movement, showing strong correlation between soma and axon signaling within subtypes.

The paper shows that somatic and axonal signaling in dopamine neurons of behaving mice are correlated, challenging previous assumptions about axonal autonomy.

This study identifies reciprocal GABAergic projections between the lateral hypothalamus and dorsal raphe nucleus that promote wakefulness through mutual inhibition and network activity modulation.

The paper introduces FLiCRE, a molecular tool for tagging calcium-activated cells, and uses it to identify and manipulate a striatal cell-type involved in aversion behavior.

The paper identifies a specific class of central amygdala neurons that are essential for synaptic plasticity in the lateral amygdala during learning.