Tatsuya Tsukahara

The paper shows that olfactory receptor expression in the nose follows a spatial code controlled by a retinoic acid gradient, aligning epithelial and brain maps.

Experiments across four laboratories found that arbaclofen rescued cognitive deficits in mouse models of 16p11.2 deletion, without sedation or significant off-target behavioral effects.

The paper investigates persistent smell loss after COVID-19 by analyzing olfactory epithelium inflammation and gene expression in patients with post-acute sequelae.

The paper examines genome architecture changes during medaka gastrulation, finding that CTCF loops form while CTCF binding sites remain fixed, and transcription precedes mature domain formation.

The paper identifies non-neuronal cell types in the olfactory system expressing SARS-CoV-2 entry genes, suggesting indirect mechanisms for COVID-19-associated anosmia.

The paper develops an algorithm to measure CpG methylation in repetitive elements using SMRT sequencing, achieving high sensitivity and precision in medaka and human genomes.