Monoclonal and Polyclonal Antibodies Research

PairedAbNGS pools 58 single-cell bioprojects of natural paired human and mouse antibodies, revealing heavy/light V gene pairing biases beyond usage frequencies and conserved CDR3-FWR2 inter-chain contacts.

YAbS catalogues over 2,900 commercially sponsored antibody therapeutics, from clinical entry since 2000 to approval, with milestone-date filtering for pipeline, trend and phase-length analyses; over 450 are openly accessible.

Over half of 614 commercial antibodies for 65 human neuroscience proteins failed a knockout-controlled assay, yet most targets had a well-performing antibody; recombinants performed best.

Consensus likelihoods from general, unsupervised protein language models evolve seven human antibodies using only a wildtype sequence and <=20 tested variants, improving binding affinity up to 160-fold.