Duo Xu

This study designs a reoriented H5 hemagglutinin vaccine to induce stem-directed antibodies, providing cross-protective immunity against diverse influenza A viruses.

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

This paper designs universal Ebola virus vaccine candidates using hyperglycosylation to focus antibody responses on conserved epitopes, showing cross-neutralizing activity against multiple orthoebolavirus species.

Consensus likelihoods from general, unsupervised protein language models evolve seven human antibodies using only a wildtype sequence and <=20 tested variants, improving binding affinity up to 160-fold.

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.