Bacteriophages and microbial interactions

This study identifies group II introns in phage genomes using RNA structure-based homology searches, revealing their prevalence across diverse phage lineages.

The paper examines the timing of P2D1 tailocin production in Dickeya dadantii 3937, showing gene expression peaks at 2 hours and tailocin concentration peaks at 6 hours post-induction, correlating with cell lysis.

This study shows that increasing defense system expression in bacteria broadens protection against phages but increases autoimmunity, revealing a tradeoff in defense system regulation.

This paper identifies complementary phage activities against Pseudomonas aeruginosa strains, showing different receptor usage and biofilm degradation efficiencies.

This study examines how antibiotic treatment affects the gut phageome, finding reduced diversity and increased virulent phage blooms, which may help restore bacterial diversity through kill-the-winner dynamics.

This study analyzes lysis modules in Streptococcus phages, identifying structural and functional diversity in endolysins and holins across 185 phage genomes.

This study uses cryo-electron tomography to reveal the spool-like architecture and infection strategies of the archaeal virus SEV1, showing its flexibility and unique assembly process.

The paper identifies a prophage protein that modulates pilus dynamics to prevent phage progeny destruction, enhancing survival through quorum sensing.

The paper studies Arctic Ocean virus communities over four years, revealing seasonality, bipolar distribution, and interactions with prokaryotes.

This study shows that phage infection reduces β-lactam resistance and virulence in MRSA by altering gene expression and genetic profiles.

The paper identifies viral contaminants in early-life gut viromes and shows the effectiveness of strain-aware decontamination to preserve biological signals.

This study shows that macrophages reduce bacteriophage density in the lungs, limiting the effectiveness of phage therapy in treating Pseudomonas aeruginosa pneumonia.

This paper describes the construction and high-yield production of virus-like particles for delivering antimicrobial genes, demonstrating their effectiveness in bacterial cultures and human cell models.

This paper isolates and characterizes a novel virulent phage against Acinetobacter baumannii, showing efficacy in a murine model and safety in high-dose administration.

This study presents the structure of the Neisseria meningitidis filamentous bacteriophage MDA{Phi}, revealing its organization and molecular mechanisms of biofilm formation and infection.

This study shows that phage resistance evolution is inhibited in mixed bacterial communities compared to isolated pairs, highlighting the complexity of coevolution in natural systems.

This study identifies CRISPR spacers and RGP gene mutations in Streptococcus mutans conferring resistance to phage ΦAPCM01, with fitness costs and potential for cross-serotype infection.

This study uses smFISH and other techniques to visualize Mimivirus transcription and translation sites in Acanthamoeba host cells, showing transcription occurs at defined spots and translation occurs in a ring around them.

This paper presents a high-resolution cryo-EM structure of the Pseudomonas phage Pa223, revealing hybrid structural features shared with P22-like, T7-like, and Litunavirus phages.

This study shows that Phage Steering with Luz19 can steer Pseudomonas aeruginosa to lose type IV pilus function even in the presence of Staphylococcus aureus.

This study identifies and characterizes the PglZ:BrxB sub-complex of BREX phage defence systems, revealing PglZ as a metal-dependent nuclease that contributes to phage defence.

This study compares phage therapy outcomes using mixed versus single bacterial isolates from an MRSA case study, finding mixed isolates better predict lung infection outcomes than blood infection outcomes.

This study investigates the infection cycle of a giant virus in a green alga, documenting ultrastructural changes and transcriptional responses at different stages of infection.

This study identifies DnaJ as essential for bNACHT25-mediated detection of RNA phages in E. coli, revealing a mechanism where phage coat protein activates the sensor without direct interaction.

The paper reveals a novel DNA homopolymer synthesis mechanism by DRT9, triggered by viral infection to induce abortive infection and population-level immunity.

Phage DisCo identifies phages that interact with specific bacterial traits by co-culturing strains with fluorescent tags and perturbations, using plaque morphology to detect infection inhibition.

This study identifies phase variation of capsular polysaccharides and other resistance mechanisms as key strategies enabling stable coexistence between gut Bacteroidales and their lytic bacteriophages.

The paper identifies two anti-phage defence systems in the WASA lineage of V. cholerae that may contribute to its epidemic success.

This study compares the virulence of three mycobacteriophages against Mycobacterium smegmatis under planktonic and early-stage biofilm conditions, finding that D29 and its cocktails show the highest virulence.

This study examines the survival and spread of engineered Mycobacterium smegmatis and its phage in soil microcosms, finding limited spread and plasmid instability.