Bacteriophages and microbial interactions

This study identifies group II introns in phage genomes using RNA structure-based homology searches, revealing their prevalence across diverse phage lineages.

The paper examines the timing of P2D1 tailocin production in Dickeya dadantii 3937, showing gene expression peaks at 2 hours and tailocin concentration peaks at 6 hours post-induction, correlating with cell lysis.

The paper analyzes 2,559 E. coli plasmids to show that antibiotic resistance genes and phage defense systems are physically linked, suggesting potential interactions between antibiotic use and phage therapy.

This study shows that increasing defense system expression in bacteria broadens protection against phages but increases autoimmunity, revealing a tradeoff in defense system regulation.

This study identifies bacterial Schlafen nucleases as antiviral effectors that target phage infection by cleaving tRNA and inducing abortive infection.

This study isolates and characterizes a new chlorovirus, BR-AMG2, from Brazil, revealing its genomic features and expanding the known diversity of giant algal viruses.

PRISM isolates, quantifies, and characterizes bacteriophages without plating, recovering non-plaquing phages and improving titering accuracy.

This paper identifies complementary phage activities against Pseudomonas aeruginosa strains, showing different receptor usage and biofilm degradation efficiencies.

The paper identifies Gp15, a phage DNA ejection protein that inhibits the CBASS effector CapV to evade bacterial antiviral defense.

The paper uses cryo-EM to determine the atomic structure of the P1 Tail Baseplate complex, revealing how its unique infection mechanism involves LTFs and baseplate movement.

This study examines how antibiotic treatment affects the gut phageome, finding reduced diversity and increased virulent phage blooms, which may help restore bacterial diversity through kill-the-winner dynamics.

This study analyzes lysis modules in Streptococcus phages, identifying structural and functional diversity in endolysins and holins across 185 phage genomes.

This paper describes a novel giant virus, PelV-1, infecting a dinoflagellate with a record-long tail and unique metabolic genes, expanding our understanding of marine virus diversity.

This study uses cryo-electron tomography to reveal the spool-like architecture and infection strategies of the archaeal virus SEV1, showing its flexibility and unique assembly process.

This study uses structure-informed methods to annotate hypothetical proteins from Pseudomonas phages, showing that combining structural and sequence-based approaches can annotate up to 43% of previously unannotated proteins.

The paper identifies a prophage protein that modulates pilus dynamics to prevent phage progeny destruction, enhancing survival through quorum sensing.

The paper studies Arctic Ocean virus communities over four years, revealing seasonality, bipolar distribution, and interactions with prokaryotes.

This study shows that bacteriophage FNU1 reduces Fusobacterium nucleatum-induced cancer cell growth and chemotherapy resistance in colon and gastric cancer models.

The paper analyzes 16 nuclease-NTPase systems to identify shared features controlling bacterial anti-phage defense, revealing universal protein complex formation and broad nucleic acid degradation capabilities.

This study shows that phage infection reduces β-lactam resistance and virulence in MRSA by altering gene expression and genetic profiles.

The paper identifies viral contaminants in early-life gut viromes and shows the effectiveness of strain-aware decontamination to preserve biological signals.

This study shows that macrophages reduce bacteriophage density in the lungs, limiting the effectiveness of phage therapy in treating Pseudomonas aeruginosa pneumonia.

This study investigates the role of the T4 phage Ac protein in infection by showing it interacts with the AcrAB-TolC efflux pump, preventing acriflavine from hindering DNA replication.

This study isolates and characterizes a temperate phage, MMB025, that targets Alicyclobacillus acidoterrestris, showing its stability under various conditions and potential as a preservation strategy against food spoilage.

This paper describes the construction and high-yield production of virus-like particles for delivering antimicrobial genes, demonstrating their effectiveness in bacterial cultures and human cell models.

This paper isolates and characterizes a novel virulent phage against Acinetobacter baumannii, showing efficacy in a murine model and safety in high-dose administration.

The paper uses phages to manipulate Variovorax species in microbiomes, confirming thiamine interdependencies and laying groundwork for targeted microbiome research.

This study presents the structure of the Neisseria meningitidis filamentous bacteriophage MDA{Phi}, revealing its organization and molecular mechanisms of biofilm formation and infection.

This study shows a TIR-SAVED effector can act independently as an antiviral defense, clearing viruses without its cyclase partner and using a host-produced second messenger.

This study shows that phage resistance evolution is inhibited in mixed bacterial communities compared to isolated pairs, highlighting the complexity of coevolution in natural systems.