Tendon Structure and Treatment

The paper identifies Gli1+ stem cells in the enthesis, shows their multipotency and therapeutic potential for tendon regeneration.

This study shows that neonatal enthesis healing occurs through non-inflammatory ECM secretion by resident cells, forming an acellular scar that restores function without inflammation or angiogenesis.

This study combines lineage tracing and spatial transcriptomics to define the activation profile and fate trajectory of adult Scleraxis-lineage cells during tendon healing, identifying key molecular regions and their roles in healing.

This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.

This study shows that suppressing IKKβ/NF-κB in Scleraxis-lineage cells during tendon healing increases scar tissue and apoptosis.

The paper identifies the developmental transition of entheses from embryonic to mature states, showing that migrating entheses replace Sox9+ progenitors with Gli1 lineage cells.