Jessica E. Ackerman

This paper develops a nanoparticle-based drug delivery system targeting tendons to improve healing by delivering Niclosamide, showing enhanced functional and mechanical outcomes compared to systemic delivery.

The paper identifies Periostin as a critical niche supporting myofibroblast dynamics and fibrosis during tendon healing, suggesting it as a therapeutic target.

This study combines lineage tracing and spatial transcriptomics to define the activation profile and fate trajectory of adult Scleraxis-lineage cells during tendon healing, identifying key molecular regions and their roles in healing.