Alayna E. Loiselle

This study shows that loss of Cochlin leads to structural and functional impairments in tendons, highlighting its role in maintaining tendon homeostasis.

This study shows that temporarily blocking Ccr2+ cell recruitment during the late inflammatory/early proliferative phase improves tendon healing mechanics, while blocking during the acute phase has no effect.

This paper develops a nanoparticle-based drug delivery system targeting tendons to improve healing by delivering Niclosamide, showing enhanced functional and mechanical outcomes compared to systemic delivery.

This study shows that increased CaV1.2 Ca2+ signaling in tendon fibroblasts leads to tendon hypertrophy, increased collagen fibrillogenesis, and improved biomechanical properties.

This study combines lineage tracing and spatial transcriptomics to define the activation profile and fate trajectory of adult Scleraxis-lineage cells during tendon healing, identifying key molecular regions and their roles in healing.

This study shows that suppressing IKKβ/NF-κB in Scleraxis-lineage cells during tendon healing increases scar tissue and apoptosis.