Inflammasome and immune disorders

This study identifies nanobodies that inhibit GSDMD pore formation without affecting caspase cleavage, providing structural insights and potential drug design frameworks.

The paper shows that caspase-1 activates GSDMA in non-mammals like amphibians, reptiles, and birds, revealing an evolutionary shift in caspase-1's target gasdermin.

This paper provides a detailed molecular network map and computational model of the NLRP3 inflammasome, integrating known mechanisms and testing the model against inhibition data.

This study shows that AA147 inhibits NLRP3 inflammasome activity by covalently modifying PDIA1, suggesting PDIA1 as a therapeutic target for inflammatory diseases.

This study shows that inhibiting NINJ1 reduces procoagulant microvesicle release and inflammation during pyroptosis, protecting against blood coagulation and lethality.

This study identifies the molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation by analyzing cleavage specificity across species.

This study shows that apoptosis and pyroptosis clear engineered Salmonella from different organs in mice, with pyroptosis being more effective in myeloid niches and apoptosis in the intestinal niche.

This study identifies how different GSDMB isoforms and protease cleavage regulate pyroptosis and mitochondrial damage in cancer cells.

This study identifies DPP9 deficiency as a Mendelian disorder causing inflammasome hyperactivity, which can be rescued by reducing NLRP1/IL-1 signaling in mice.

This paper identifies proteolytic cleavage as the mechanism regulating fungal gasdermin activity, showing that HET-Q1 is cleaved by HET-Q2 to induce cell death and that gasdermin genes are clustered with protease genes.

This study shows that NLRP3 inhibition after reperfusion reduces brain injury in ischemia by protecting the blood-brain barrier and reducing inflammation.

The paper identifies a SNP in the 3' UTR of the Pycard gene in mice that affects mRNA stability and inflammasome activity through CRISPR/Cas9 editing.

The paper shows that PPARA upregulates Gm15441, which suppresses TXNIP and reduces NLRP3 inflammasome activation during metabolic stress.

This study identifies a novel mutation in A20 causing haploinsufficiency and shows it impairs the protein-protein interactome, leading to enhanced NLRP3 inflammasome activation through caspase-8.