Topic · Microbiology · Immunology and Microbiology

Antimicrobial Peptides and Activities

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

Synthetic Biology·Nature CommunicationsPeer-reviewed·Nov 8, 2023
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Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides
Amir Pandi, David Adam, Amir Zare…+19 more authors·Tobias J. Erb
Autoencoder design plus a roughly 24-hour cell-free screen tested 500 candidates over five rounds, finding 30 functional AMPs; six were broad-spectrum with no resistance emerging in E. coli.
173 citationstop 1%
E. coli·bacteria (other)
·𝕏 Post·Bluesky
Bioinformatics·bioRxivPreprint·Jul 12, 2019
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Deep learning regression model for antimicrobial peptide design
Jacob J. Witten, Zack Witten
A CNN trained on 4050 E. coli peptide MIC records predicts activity, outperformed other AMP classifiers with random negatives, and guided two designed peptides active against three pathogens.
100 citations
E. coli·bacteria (other)
·𝕏 Post·Bluesky