Transplantation: Methods and Outcomes

The paper uses single-cell RNA-sequencing to identify cell-specific gene expression patterns in high-grade cardiac allograft vasculopathy, finding increased CD4+ T central memory cells and monocytes, and 745 differentially expressed genes.

This study shows that MerTK-dependent efferocytosis by monocytic-MDSCs reduces post-lung transplant ischemia-reperfusion injury.

This study uses machine learning to identify cytokines predictive of primary graft dysfunction in lung transplantation, finding BAL fluid at 2h post-transplant as the strongest predictor.

The paper identifies ventricle-specific DNA methylation patterns in cell-free DNA that correlate with acute cellular rejection in heart transplant recipients.

This study shows donor-derived mitochondrial DNA variants trigger allo-specific immune responses in transplant patients, with higher IFN-gamma release compared to recipient-derived peptides.