Jeffrey C. Rathmell

The paper shows that glutaminolysis and mitochondrial metabolism are conditionally crucial for B cell differentiation and cytokine signaling, revealing metabolic regulation of plasma cell generation and cytokine receptor signaling.

This paper develops and validates nbLIBRA-seq, a method for high-throughput antigen-specific nanobody discovery in immunized alpacas, demonstrating its effectiveness in identifying nanobodies against CD71 and viral antigens.

This study identifies glutaminase as critical for α cell mass and glucagon secretion by linking glutamine metabolism to amino acid sensing and growth.

This study identifies ARG2 deficiency in tumor cells as a driver of lung metastasis via NOS2-dependent Th17 responses in immune-competent hosts.

The paper identifies a hypometabolic CD8+ T cell state, TEff-2, linked to respiratory failure and mortality in critical illness using single-cell RNA sequencing.

This paper shows that BCL6 in T cells promotes type 1 diabetes by enabling anti-insulin B cells to become pathogenic, and that blocking BCL6 in T cells prevents diabetes even when insulin-reactive B cells are present.

This study shows dehydration increases intracellular lipid synthesis and accumulation by promoting glutamine oxidation and mitochondrial metabolic remodeling.

This study shows that estrogen receptor-alpha signaling in T cells increases Th17-mediated airway inflammation in obese female mice and that Th17 cells are more frequent in women with asthma compared to men.

This study shows that loss of the transferrin receptor (CD71) in Treg cells leads to tissue-specific inflammation and autoimmunity, highlighting the role of CD71-iron metabolism in Treg stability and function.

The paper examines metabolic adaptations in CD4 T cells of critically ill patients with and without sepsis, identifying subset-specific changes linked to immunosuppression and clinical outcomes.

This study shows that Trsp is essential for T cell development and function, particularly regulatory T cells, and its deficiency leads to fatal autoimmunity.

This study identifies AR4 (cadA) as critical for UPEC survival during early intracellular infection by showing its induction and role in lysosome resistance.

This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.

This study shows that impaired oxidative phosphorylation, driven by NDUFA4L2, promotes EMT and metastasis in renal cell carcinoma by altering chromatin accessibility.

This paper identifies a founder mutation in G6PC3 causing congenital neutropenia and shows it leads to loss of protein function and altered glycolysis.

This study shows that glutaminolysis supports lupus Tfh cell function, and its inhibition reduces autoantibody production and disease in lupus-prone mice.

The paper uses single-cell RNA-sequencing to identify cell-specific gene expression patterns in high-grade cardiac allograft vasculopathy, finding increased CD4+ T central memory cells and monocytes, and 745 differentially expressed genes.

The paper introduces NSC-seq, a CRISPR-based molecular clock to track temporal and clonal events in development and precancer, revealing polyancestral initiation in colonic precancers.

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

This paper introduces NSC-seq, a direct sgRNA capture method for single-cell CRISPR screens using standard knockout libraries, and characterizes sgRNA expression in three whole-genome libraries.

This study shows that glucose influx is critical for germinal center function and plasma cell production, but plasma cells can also use alternative hexose sugars for antibody secretion.

This study identifies tissue- and subset-specific roles of SLC38A1 in Th1 cell function during inflammation, showing its importance in EAE and IBD but not lung inflammation.

This study shows SCLC cells exist in a continuum of plastic states rather than discrete subtypes, with gene expression patterns linked to cancer hallmarks and potential therapeutic targets.

This study shows that macrophages in Notch1+/- mice promote osteogenic calcification in aortic valves through STAT3 splicing changes and increased recruitment and polarization.