Bone Metabolism and Diseases

Genetic Analysis of Osteoblast Activity Identifies Zbtb40 as a Regulator of Osteoblast Activity and Bone Mass

The paper identifies Zbtb40 as a regulator of osteoblast activity and bone mass through genetic analysis in mice, showing reduced BMD and mineralization upon Zbtb40 knockdown.

Bone-targeted lncRNA OGRU alleviates unloading-induced bone loss via miR-320-3p/Hoxa10 axis

This study identifies OGRU, a lncRNA that alleviates unloading-induced bone loss by regulating the miR-320-3p/Hoxa10 axis in osteoblasts.

MiR-146a controls age related bone loss

This study identifies miR-146a as a key regulator of age-related bone loss, showing its role in controlling bone homeostasis through Wnt signaling and its potential as a therapeutic target.

Identification of a Central Neural Circuit that Regulates Anxiety-induced Bone Loss

This study identifies a GABAergic neural circuit from the forebrain to hypothalamus that regulates anxiety-induced bone loss.

Exposure to the RXR agonist SR11237 in early life causes disturbed skeletal morphogenesis in a rat model

This study shows that RXR agonist SR11237 disrupts skeletal development in rats and mice by causing growth plate dysmorphia and impaired long bone growth.

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

This study shows MACF1 is essential for bone formation by enabling SMAD7 nuclear translocation in MSCs, leading to ossification retardation and bone loss in mice.

CYLD, a Mechanosensitive Deubiquitinase, Regulates TGFβ for Load-induced Bone Formation and Mediates PGE2-dependent Repression of TGFβ Signaling in Osteocytes

The paper identifies CYLD as a mechanosensitive deubiquitinase that represses TGFβ signaling in osteocytes through PGE2 and EP2, facilitating load-induced bone formation.

Satb2 regulates proliferation and nuclear integrity of pre-osteoblasts

This study investigates Satb2's role in pre-osteoblast proliferation and nuclear integrity, finding it regulates cell cycle progression and DNA replication, with potential implications for skeletal defects and cancer.

Periosteum-derived Osteocrin regulates bone growth through both endochondral ossification and intramembranous ossification

This study shows that Osteocrin promotes both endochondral and intramembranous ossification in long bone growth by enhancing CNP signaling.

Osteocyte death and bone overgrowth in mice lacking Fibroblast Growth Factor Receptors 1 and 2 in mature osteoblasts and osteocytes

This study shows that loss of FGFR1 and FGFR2 in mature osteoblasts/osteocytes leads to osteocyte death and high bone mass with impaired biomechanical properties in mice.

Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass

This study identifies integrin alpha11 as the receptor for Osteolectin, showing its role in osteogenic differentiation and bone mass maintenance through Wnt pathway activation.

A novel nonsense mutation c.424G>T (p. G142X) in the first exon of XLas leading to osteopetrosis

The paper reports a novel nonsense mutation in XLas causing osteopetrosis and high bone mass by disrupting the skeletal response to parathyroid hormone.

Bone remodeling: A tissue-level process emerging from cell-level molecular algorithms

This paper proposes a minimal model of bone remodeling that shows efficient BMU operation emerges from simple cell-level decisions and interactions.