Developmental BiologyMolecular Biology of the CellPeer-reviewed
A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions
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University of California, San Francisco
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2 papers
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Jacqueline Nguyen, Ramin Massoumi, Tamara N. Alliston
The paper identifies CYLD as a mechanosensitive deubiquitinase that represses TGFβ signaling in osteocytes through PGE2 and EP2, facilitating load-induced bone formation.