Urinary Tract Infections Management

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli

This study evaluates how the urinary microenvironment and fluid flow affect antibiotic and phage therapy against UPEC, showing that physiological conditions reduce treatment efficacy.

Chondroitin sulfate degradation bolsters Proteus mirabilis growth and colonization of the catheterized urinary tract

This study shows that Proteus mirabilis uses chondroitin sulfate degradation to support growth and colonization in catheterized urinary tract infections.

Diabetes mellitus affects urinary tissue tropism of group B streptococci in a sex-dependent manner

This study shows diabetes increases GBS urinary tract infection susceptibility and dissemination, with sex-dependent differences in tissue tropism and immune response.

Selective Sugar Transport Supports Proteus mirabilis Fitness in the Urinary Tract

This study identifies key sugar transporters in Proteus mirabilis that support its fitness during urinary tract infections and shows that host metabolic conditions can influence infection severity.

Emerging Pathogens in Urinary Tract Infections: Virulence and Phenotypic Characterization of Pseudomonas aeruginosa strains

This study characterizes Pseudomonas aeruginosa as an emerging uropathogen in UTIs, identifying antibiotic resistance patterns, virulence factors, and associations with patient demographics and catheter use.

Unmasking Pathogen Traits for Chronic Colonization in Neurogenic Bladder Patients

The paper studies microbial colonization in neurogenic bladder patients, identifying patterns of bacterial persistence and mutations linked to immune evasion and phage resistance.

A bioengineered human urothelial organoid model reveals the urine-urothelium interplay in tissue resilience and UPEC recurrence in urinary tract infections

The paper develops a human urothelial organoid model to study urine-urothelium interactions in UTI resilience and UPEC recurrence, finding that high-solute urine weakens tissue and promotes CWD UPEC formation.

SimUrine: A Novel, Fully Defined Artificial Urinary Media for Enhanced Microbiological Research of Urinary Bacteria

The paper introduces SimUrine, a fully defined synthetic urine medium that supports diverse urinary microbiome growth and reveals novel microbial interactions and antimicrobial susceptibility patterns.

A simple ex vivo bladder infection model permits study of host-pathogen interactions in UTI

This paper introduces an ex vivo bladder infection model using discarded mouse tissue to study host-pathogen interactions in UTI, showing comparable bacterial burden to in vivo models.

Prediction of symptomatic and asymptomatic bacteriuria in spinal cord injury patients using machine learning

This paper develops a machine learning framework to predict symptomatic and asymptomatic bacteriuria in spinal cord injury patients using microbiome data, achieving high accuracy in classification.

Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection

The paper identifies microbiome-metabolite interactions and metabolic markers associated with recurrent urinary tract infections using metagenomic and metabolomic data.

Evidence for an indigenous female mouse urobiome

The paper investigates the presence of an indigenous urobiome in female mice by analyzing urine samples using different extraction methods and sequencing techniques.

Obesity promotes urinary tract infection by disrupting urothelial immune defenses

This study shows obesity increases UTI risk by altering bladder immune defenses through focal adhesion kinase activation in mice and human cells.

Metatranscriptomics-based metabolic modeling of patient-specific urinary microbiome during infection

This paper uses metatranscriptomics and metabolic modeling to analyze patient-specific urinary microbiomes during infection, identifying metabolic dependencies and potential interventions for antibiotic-resistant UTIs.

PHENOTYPIC CHARACTERIZATION AND BACTERIAL INTERACTIONS OF THE COMPLEX MICROBIAL POPULATION IN URINARY DOUBLE-J CATHETERS

This study characterizes bacterial interactions and phenotypes of uropathogens isolated from urinary catheters, revealing biofilm-forming capabilities and multidrug resistance in key species.

Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI

This study identifies two monoclonal antibodies against FimH adhesin that protect mice from E. coli UTI by sterically blocking FimH function, offering an antibiotic-sparing treatment strategy.

Short- and mid-term temporal variability of the human urinary microbiota: an observational cohort study

This study examines the temporal variability of the human urinary microbiota over 3-40 months, finding that paired samples share over 60% of bacterial community relative abundance, with little variation in alpha and beta diversity.

The urinary microbiome in association with diabetes and diabetic kidney disease: A systematic review

This paper reviews studies on the urinary microbiome's association with diabetes and diabetic kidney disease, finding reduced microbial diversity in diabetic individuals and further decline with kidney disease progression.

Metabolomics survey of uropathogenic bacteria in human urine

The paper surveys the metabolic activities of common uropathogenic bacteria in human urine using LC-MS, identifying four distinct metabolic clades.

Structure and diversity of urinary cell-free DNA informative of host-pathogen interactions in human urinary tract infection

This study uses urinary cell-free DNA to monitor host and pathogen dynamics in urinary tract infections, revealing insights into microbiome composition, antimicrobial susceptibility, and kidney injury.