Nikolche Gjorevski

This paper introduces SHOCOs, a modular system using patient-derived colorectal tumor organoids and fibroblasts to model tumor microenvironments, showing improved immune response and stromal effects on therapy.

This paper introduces a high-throughput histopathology workflow for complex in vitro models using 3D-printed histomolds, enabling efficient processing and analysis of multiple samples.

The paper develops a human urothelial organoid model to study urine-urothelium interactions in UTI resilience and UPEC recurrence, finding that high-solute urine weakens tissue and promotes CWD UPEC formation.

This paper introduces vascularized tumor organoids (VascO) to model tumor microenvironments for immunotherapy testing, showing they can assess drug safety and efficacy in a patient-specific context.

This study uses deep learning and spatial data to show how tumor architecture and cell states co-evolve, influencing colorectal cancer outcomes.

The paper develops engineered human gut tissues to study host-microbe interactions and identifies an epithelial gene regulatory network in response to Salmonella Typhimurium infection.

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

This paper develops human lung alveolar immuno-organoids with autologous immune cells to model immune-epithelial interactions and study inflammation-related pulmonary side effects.

This study develops human intestinal immuno-organoids (IIOs) that integrate tissue-resident immune cells, enabling the study of intestinal inflammation and immune responses in disease contexts.