Michael T. Laub

The paper studies microbial colonization in neurogenic bladder patients, identifying patterns of bacterial persistence and mutations linked to immune evasion and phage resistance.

DefensePredictor combines ESM2 protein language model embeddings with genomic context features in a gradient boosting classifier to identify prokaryotic anti-phage defense genes, validating 45 previously unknown Escherichia coli systems.

This study identifies SNIPE as a bacterial membrane-bound nuclease that directly cleaves phage DNA during genome injection, providing a novel mechanism for distinguishing self from non-self.

This study shows that viral SSB-bound ssDNA activates the bacterial anti-phage defense system DARNA by recognizing a signal promoted by viral proteins, enabling broad virus detection without auto-immunity.

The paper identifies a novel anti-viral mechanism where CmdT, an ADP-ribosyltransferase, targets mRNA to block translation and inhibit phage replication.

This study shows that the bacterial immunity protein CapRelSJ46 can sense two distinct phage proteins using the same domain, highlighting its versatility in anti-phage defense.

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

This paper develops synthetic phosphorylation-based signaling networks in mammalian cells that are tunable, precise, and robust to perturbations.

The paper introduces GapR-seq, a method to map positive supercoiling in genomes, and finds it widespread, associated with transcription and specific genomic features in E. coli and yeast.

This study investigates the portability of RecT-mediated homologous recombination across bacterial species, finding that compatibility with the host's single-stranded DNA-binding protein determines functionality.

The paper introduces eADAGE, an ensemble method to extract stable expression signatures from public data, revealing a phosphate starvation response in Pseudomonas aeruginosa controlled by PhoB and requiring KinB.