Microfluidic and Bio-sensing Technologies

Protruding Geometry Provides Potential Homing Sites of Circulating Tumor Cells

This study identifies protruding vessel geometries as critical sites for CTC accumulation and shows that molecular mechanical coupling influences their retention.

Automated High-Throughput Microfluidic Platform for Cell Pairing and Chemical Fusion

This paper introduces an automated microfluidic platform for high-throughput cell pairing and chemical fusion, achieving higher efficiency and throughput than previous methods.

Enriching microlaser-labelled cells by commercial flow cytometry-based cell sorting systems

This paper demonstrates the use of commercial flow cytometry to sort HEK293T cells with controlled numbers of microlaser particles, enabling defined cellular labeling and spheroid formation.

Passive Cell-Flux Partitioning Enables Single-Cell-Constrained Impedance Sensing From High-Density Microbial Cultures

This paper introduces a microfluidic chip that enables single-cell-constrained impedance sensing in high-density microbial cultures for real-time monitoring in industrial biomanufacturing.

Cell-specific heteroclinic orbits govern interaction dynamics in inertial microfluidics for circulating tumour cell separation

This study shows that cell-specific heteroclinic orbits and migration rates affect WBC carryover in inertial microfluidics for CTC separation.

Acoustofluidic Active Flow Sculpting Enables Dynamic, Reconfigurable Cross-Sectional Patterning

This paper introduces ActiSculpt, an acoustofluidic platform that enables dynamic, reconfigurable cross-sectional patterning of soft materials in continuous flow.

Label-free Isolation of Heterogeneous Breast Cancer Cell Populations via Insulator-Based Dielectrophoresis

This paper develops a microfluidic platform using insulator-based dielectrophoresis to isolate breast cancer cells from blood with high recovery and purity.

Microfluidic T-Chip enables one-step clinical-scale T-cell purification from blood products for CAR T-cell manufacturing

The paper introduces a microfluidic T-Chip for one-step clinical-scale T-cell purification from blood products, achieving high purity, viability, and recovery of CD3+ T cells for CAR T-cell manufacturing.

Randomized Spatial Barcoding for Time-Lapse Flow Cytometry

The paper introduces RASPBerry, a hydrogel-based spatial barcoding platform for time-lapse flow cytometry, enabling tracking of suspended cells with high accuracy and throughput.

Hydrodynamic shear enables enrichment of functional tumor antigen-reactive T cells

This paper introduces a microfluidic platform using hydrodynamic shear to enrich antigen-specific T cells, achieving 35-fold enrichment from peripheral blood mononuclear cells.

Magnetic Levitation of Intact Tumor Biopsies Reveals Multivariate Biophysical Signatures of Breast Cancer Aggressiveness

This paper applies magnetic levitation to breast cancer biopsies to generate biophysical signatures linked to tumor aggressiveness and clinical subtypes.

A High-Fidelity 3D Fluid-Structure Interaction Framework for Predictive Microfluidic Design

This paper develops a 3D fluid-structure interaction framework for microfluidic design, validated against experiments to predict particle transport and separation with sub-micron accuracy.

Rapid and affordable generation of compensation beads for nanoscale flow cytometry

The paper describes a method to rapidly create affordable compensation beads for nanoscale flow cytometry compatible with various antibodies.

Scaffold-Free Acoustic Levitation Platforms Enable Scalable Culture of Neuronal Spheroids and Assembly of Layered Cortico - Striatal Assembloids

This paper introduces scaffold-free acoustic levitation platforms for culturing neuronal spheroids and assembling layered cortico-striatal assembloids, showing viability and functional maturation.

Microfluidic Separation of Adipocytes

This paper develops a microfluidic device for sorting mature adipocytes by size, achieving high recovery, purity, and maintaining hormonal response.

CellTrap: A Microfluidic Platform Enabling Cell-Cell Interactions at Variable Effector to Target Ratios

CellTrap enables long-term, single-cell analysis of immune-cancer interactions by controlling effector-to-target ratios, showing enhanced immune activity with higher ratios.

Numerical study of the size-based, shear-induced separation of circulating tumour cells from white blood cells in liquid biopsies

This study uses simulations to show that circulating tumour cells enhance white blood cell migration in microfluidic systems, affecting separation efficiency.

Ridge-assisted Micro Positioning of Cells and Particles in a Microchannel

This paper introduces RAMP, a microfluidic method for precisely positioning cell streams in microchannels across a wide flow rate range, independent of particle size.

Immune Cells Infiltration of Patient Derived Glioblastoma Cells spheroids in Acoustic Levitation in Bulk Acoustic Wave devices

The paper describes an acoustofluidic device for creating 3D tumoroids from patient-derived glioblastoma cells and shows immune cell infiltration in these tumoroids.

Isolation of individual natural killer cells from deep, high-aspect ratio microwell arrays - an evaluative study

This study evaluates a microwell system for isolating individual NK cells, demonstrating its viability and potential for functional screening but noting its limited throughput.

3D-Printed Magnetic Levitation Device with Deep Learning-Assisted Particle Tracking and Analysis for High-Throughput Sorting

This paper introduces a 3D-printed magnetic levitation device with automated analysis for high-throughput particle sorting, achieving high accuracy and resolving small density differences.

Predicting Tumor Mutational Burden from UHF-Dielectrophoresis Crossover Frequency

This paper proposes using UHF-dielectrophoresis crossover frequency (EMS) to predict tumor mutational burden (TMB) as a rapid, low-cost alternative to whole exome sequencing.