Bhupinder S. Shergill

This paper introduces a microfluidic platform using hydrodynamic shear to enrich antigen-specific T cells, achieving 35-fold enrichment from peripheral blood mononuclear cells.

The paper develops a microfluidic BBB model to study nanoparticle trafficking and accumulation, finding that ligand presentation and membrane composition, not size or stiffness, govern BBB penetration.

This study shows that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis in colorectal cancer, and inhibiting NET formation reduces necrosis and improves chemotherapy outcomes.

This paper introduces a microfluidic method to assess B cell affinity to antigens under force, showing it can enrich high-affinity B cells and correlate with solution-based antibody affinity.