Immune cells in cancer

The paper identifies human myelocyte and metamyelocyte-stage neutrophils as immunosuppressive cells that promote cancer progression and suggests targeting them for immunotherapy.

This study identifies S100a4+ alveolar macrophages that promote lung cancer progression by enhancing angiogenesis through fatty acid metabolism in precancerous lesions.

In THP-1 cells, hypoxia drives Lyn-dependent YY1 phosphorylation and phase separation; YY1 and NUSAP1 SUMOylate and stabilize HIF-1α, and degrading YY1 curbs mouse prostate tumors.

This study investigates how pulmonary macrophage subsets respond metabolically to polarizing stimuli in vivo, revealing distinct metabolic profiles between alveolar and interstitial macrophages.

This study identifies NRF2 as a stress-response axis that polarizes tumor macrophages into immunosuppressive, therapy-resistant states, and shows that inhibiting NRF2 can restore immunotherapy efficacy.

This study investigates the role of immunosuppressive neutrophils in SBRT-treated murine PDAC and shows that re-wiring them with IL-12 improves treatment efficacy.

The paper identifies tumor-inhibitory fibroblasts that produce fibronectin, which activates signaling pathways in neighboring cells to enhance immune response against early cancer.

This study identifies ZEB1 as a key regulator of TAM-mediated T cell trafficking, enhancing CTL recruitment and immunosurveillance in tumors and metastases.

This study shows that macrophage clusters enhance tumor phagocytosis through coordinated intrudopodia extending between cancer cells.

The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.

This paper develops a mouse model of HER2-positive breast cancer cerebellar metastases and identifies IL34-induced Arg1+ macrophages as key drivers of tumor growth, showing that targeting CSF1R can reduce metastases.

The paper identifies mitochondrial metabolism as a key regulator of phagocytic function in human lung monocytes and macrophages, showing that succinate supplementation enhances these functions and promotes macrophage differentiation.

This study shows that fat-rich diets enhance antitumor immunity in the lungs by reprogramming intrapulmonary neutrophils through vascular endothelial cell interactions.

This study shows that modulating GSK3 activity reprograms GM-CSF-dependent macrophages to exhibit features of M-CSF-dependent macrophages and interstitial macrophages.

The paper identifies inflammatory cytokine-producing TAMs and PD-L1 tumor expression as poor prognosis factors in cutaneous melanoma using single-cell RNA sequencing and microscopy.

This study identifies PYK2 as an immunomechanical checkpoint governing monocyte-to-macrohage differentiation in PDAC, showing its role in mechanotransduction and improved immunotherapy response.

This study shows that peripheral ischemia accelerates hematopoietic aging, promoting tumor growth by skewing immune cell composition and enhancing immunosuppression.

This study identifies VSIG4-expressing peritoneal macrophages as key players in anti-parasitic and anti-metastatic responses in the peritoneal cavity.

This study shows that loss of neurofibromin activates GLUT1 in macrophages, leading to increased glycolysis and retinal neovascularization in NF1 mice.

The paper identifies iron-recycling macrophages in bone metastases that support tumor growth and anemia by hijacking erythropoiesis and enabling tumor cell erythroblast mimicry.

This study uses single-cell profiling to analyze immune cell changes in murine skin tumors, identifying macrophages as key regulators and highlighting immunosuppressive shifts during tumor progression.

This paper investigates negative feedback mechanisms in immune tolerance and tumor immune escape by analyzing gene expression patterns in response to sustained antigen stimulation.

This study identifies key kinases and transcription factors regulating immunosuppressive macrophages and validates proteomic signatures for detecting pro-inflammatory macrophages in tumors.

This study shows that aging alters macrophage phenotypes in the melanoma microenvironment, with TREM1 and TREM2 playing distinct roles in tumor progression and metastasis in aged mice.

This study identifies CXCR4-expressing tumor-associated macrophages in bladder cancer and shows that targeting them improves immunotherapy outcomes in mice and patients.

The paper identifies two distinct pathways for replenishing resident peritoneal macrophages after injury, with differing reliance on monocytes and intermediate stages.

This study shows that Pseudomonas aeruginosa-infected MDSCs enhance mouse survival in lung infections by reducing lymphocyte activity and promoting epithelial repair.

This study identifies six myeloid cell clusters in melanoma using scRNA-seq, finding that M_C1 subtype frequency predicts survival and immunotherapy response.