Ramesh V. Nair

This study identifies sex-specific changes in bone and senescence-related proteins in neurodegenerative diseases using plasma proteomics.

The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.

This study identifies CES1 deficiency as a driver of metabolic reprogramming and endothelial dysfunction in pulmonary arterial hypertension, showing its role in lipid metabolism and oxidative stress.

This paper identifies CDC14A and KMT5A as regulators of concentric vs. eccentric cardiac remodeling through epigenomic control of gene transcription, with CDC14A as a potential therapeutic target for heart failure.

This study shows that loss of ROR2 leads to endothelial dysfunction in PAH through inappropriate integrin beta 1 activation, impairing barrier integrity and angiogenesis.

This study identifies six myeloid cell clusters in melanoma using scRNA-seq, finding that M_C1 subtype frequency predicts survival and immunotherapy response.

This study quantifies gene expression changes in Staphylococcus epidermidis under varying glucose and temperature conditions, identifying glucose-responsive genes and a heat-shock response similar to related species.

The paper establishes a cardiomyopathy stem cell biobank and identifies transcriptomic subtypes and drug response in iPSC-derived cardiomyocytes.

The paper shows that newly repopulated spinal cord microglia have a unique transcriptome linked to pain resolution in a tibial fracture model.

The paper shows how KLF4 interacts with SWI/SNF to increase chromatin accessibility at enhancers under laminar shear stress, promoting endothelial homeostasis and suppressing inflammation.

The paper shows that the miR-193b~365 microRNA cluster downstream of Fezf2 represses Mapk8 and affects dendritic branching in cortical projection neurons.

The paper identifies a microRNA cluster unique to placental mammals that promotes corticospinal neuron identity by repressing LMO4, a callosal gene, thereby contributing to neuronal subtype diversity in the mammalian brain.

This study identifies NF90/ILF3 as a transcription factor that promotes proliferation over differentiation in K562 cells by hierarchically regulating key transcription factors.

This study shows aged blood reduces hippocampal neurogenesis and activates microglia via VCAM1 at the BBB, and blocking VCAM1 reverses these effects.