Curcumin's Biomedical Applications

This study identifies EF-24 targets and their antitumorigenic mechanisms in leukemia cells using whole-transcriptome profiling.

This study evaluates nanoparticle formulations of curcumin and piperine for modulating steroid biosynthesis in prostate cancer cells, finding that curcumin-piperine nanoparticles most effectively inhibit key enzymes and reduce androgen levels.

This study shows curcumin reduces arsenic trioxide-induced behavioral, oxidative, and morphological damage in mice striatal regions.

This study shows that curcumin protects myeloid cells from cadmium and H2O2-induced oxidative stress through Nrf2/ARE signaling and autophagy.

This study evaluates the effects of non-micronized and micronized curcumin on stress-induced behavioral and neurochemical changes in zebrafish, finding no protective effects.

This study shows that micronized curcumin increases locomotion in zebrafish larvae without affecting other behaviors or oxidative status.

This study compares the antioxidant effects of curcumin and micronized curcumin in vitro and in vivo, finding that micronization enhances antioxidant activity and mitigates stress-induced neurochemical changes in zebrafish.

This study shows curcumin improves metabolic issues in a Drosophila Huntington's disease model by reducing body weight abnormalities, lipid content, and ROS levels, and enhancing survival and locomotion.

This study investigates the binding potential of curcuminoids to CK1 and GSK3B in the Wnt/β-catenin pathway using molecular docking and evaluates their drug likeness and pharmacological properties.

This study shows curcumin and its derivative didemethylcurcumin modulate proteasome activity in a concentration-dependent biphasic manner, with curcumin being more effective.

This study shows curcumin causes mild anemia, lowers iron stores, worsens colitis, and reduces survival in DSS-induced colitis mice on an iron-sufficient diet.