Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology

Prion Diseases and Protein Misfolding

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

Molecular Biology·bioRxivPreprint·Sep 29, 2026
✦ In-depth digestWant to read
Prion Protein Deficiency Results in Synaptic, Neural Network and Behavioral Alterations
Anna Burato, Alessio Di Clemente, Camilla Lodetti…+11 more authors·Giuseppe Legname
Lifelong prion protein (PrP) loss in mice lowers excitatory synaptic proteins, makes network bursts in mature cortical cultures rarer and neuronal activity more correlated, and increases adult dimming-disk escapes.
1 citation
mouse·bulk RNA-seq
·𝕏 Post·Bluesky
Neuroscience·Nucleic Acids ResearchPeer-reviewed·Mar 19, 2026
✦ In-depth digestWant to read
Divalent siRNA for prion disease
Juliana E Gentile, Taylor L Corridon, Fiona E. Serack…+24 more authors·Sonia M. Vallabh
Divalent siRNA 2439-s4 lowers human PrP to 17% residual in transgenic mouse brain after one dose, and a separate mouse Prnp-targeting siRNA extends survival in prion-infected mice.
28 citationstop 1%
mouse·human
·𝕏 Post·Bluesky