Tryptophan and brain disorders

This study identifies transcriptomic changes in non-human primate brains exposed to maternal immune activation, revealing alterations in retrotransposition, synaptic connectivity, and myelination.

The paper applies penalized regression to a dataset of 26 variables from 67 male pups to identify factors associated with maternal immune activation (MIA) and its effects on neurodevelopment.

This study examines the effects of maternal immune activation on neurobehavioral development in rhesus monkey offspring, finding reduced gray matter volume in specific brain regions.

This study shows that asperosaponin VI reduces depressive-like behaviors in LPS-treated mice by suppressing microglial activation and the TLR4/NF-κB-induced IDO pathway.

This study uses bidirectional Mendelian randomization to investigate causal relationships between inflammatory markers and depression, finding a causal effect of IL-6 on major depressive disorder.

This study identifies variability factors in maternal immune activation models and shows baseline immune responsiveness predicts offspring outcomes.

This study shows that acute mild inflammation from typhoid vaccination alters neurophysiological processes related to attention, specifically increasing alpha suppression in alerting without affecting behavior.

This study shows that maternal immune activation increases the volume of the diagonal domain in rat brains during early postnatal development, with potential sex differences.

This study shows maternal immune activation causes age-specific changes in cytokine receptor expression in offspring's frontal cortex, with potential implications for neuropsychiatric disorders.

This study uses machine learning to identify predictors of health-related quality of life in schizophrenia, finding that neuro-immune biomarkers and cognitive impairments significantly impact HR-QoL.

This paper investigates how immune activation and tryptophan catabolite pathway activity contribute to memory impairments and schizophrenia symptom dimensions.

The paper evaluates 42 inflammatory markers in MDD cases and controls, finding strong confounding effects and limited predictive power of individual markers for MDD diagnosis.

This study finds elevated peripheral C-reactive protein (CRP) is associated with treatment-resistant depression, childhood adversity, and specific depressive and anxious symptoms.

This paper reviews peripheral biomarkers in major psychiatric disorders, finding that five molecules show similar variation across disorders, suggesting transdiagnostic systemic consequences rather than specific diagnostic markers.