Innovative Microfluidic and Catalytic Techniques Innovation

This paper introduces an open-source, 3D-printable droplet microfluidics platform with stroboscopic microscopy for stable droplet generation and low-flow control.

The paper develops a microfluidic screening platform to identify sialic acid-active enzymes in metagenomes, discovering a new aldolase enzyme from garden soil.

The paper introduces OASSIS, an open-format digital bioassay platform that enables sensitive, low-complexity RNA detection for point-of-care testing.

This paper introduces a step-emulsion platform for scalable microgel fabrication that is robust, user-agnostic, and compatible with various materials and viscosities.

LMNOP-bot automates microfluidic material library generation, increasing throughput 50x and enabling precise, reproducible deposition into standard well plates.

This paper introduces a simple method to track bacterial growth in droplets over 12 hours, revealing growth rate heterogeneity not apparent in batch assays.

This paper introduces a droplet microfluidic platform that significantly improves DNA delivery efficiency in non-model organisms through enhanced conjugation.

This paper describes a simple method for preparing functional PFPE-based fluorosurfactants in biology labs, enabling low-cost and customizable droplet microfluidic applications.

This paper introduces a method to precisely load scarce reagents on droplet microarrays, reducing material usage and enabling high-throughput assays with minimal volumes.

The paper introduces a droplet cytometry and sorting platform for fast and accessible screening of yeast cells based on fluorescence signals.

MusTer improves single-cell sequencing by reducing doublets, enhancing signal-to-noise ratio, and improving cell clustering in maize leaf ATAC-seq.

This paper develops a microfluidic device called LARLM for producing uniform lipid nanoparticles (LNPs) with high productivity and demonstrates improved bioavailability of loaded drugs in vitro.

This paper introduces a dual-channel FRET-based droplet sorting system to enhance terminator polymerase engineering, achieving 30-fold enrichment of active variants in a single round.

The paper shows that lower interfacial tension, achieved by surfactant concentration, can overcome the challenges of high viscosity in microfluidic droplet generation using basement membrane extract.

The paper presents a space-efficient method for generating uniform hollow agarose microcapsules using a sealed bottle and vortex mixer, enabling high-throughput encapsulation in confined environments.

The paper introduces a microfluidic device called PicoSorter for high-throughput selection of cellulolytic microorganisms using droplet-based assays and sorting.

This paper develops a method to create uniform sodium alginate microdroplets using pH-sensitive cross-linkers and geometric control, achieving low variation and stable gels.

This paper introduces a light-controlled picodroplet reactor platform capable of executing multi-step biochemical reactions with precise reagent control and real-time monitoring.

The paper demonstrates a shake reaction method that significantly reduces reaction times for both organic and biological processes by using micro-nano droplets formed through shaking.

The paper presents a label-free image analysis pipeline using Cellprofiler to identify microfluidic droplets, microplastic particles, and bacterial growth without fluorescent labels.

This study investigates the factors affecting GUV production via double emulsion microfluidics and shows that high glycerol and P188 concentrations are unnecessary, enabling more reliable and accessible GUV production.

The paper introduces Cocoa-seq, a microfluidic workflow for high-throughput analysis of microbial co-cultures, and benchmarks it using model communities and fluorescence microscopy.

The paper develops a statistical model to predict data throughput in multi-cell, multi-type droplet microfluidics experiments and identifies factors affecting its accuracy.

This paper introduces a microfluidic device to study Streptomyces lifecycle at the single-cell level, enabling observation of aerial hyphae development and phenotypic assays.

This paper introduces a cost-effective digital PCR method using microfluidic droplet printing on glass substrates, enabling reliable and affordable quantitative results.

The paper introduces MINI-Drop, a method to infer microbial interactions in microfluidic droplets, showing it can accurately determine pairwise and higher-order interactions.