Topic · Pharmacology · Pharmacology, Toxicology and Pharmaceutics

Drug-Induced Hepatotoxicity and Protection

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Pharmacology & Toxicology·Archives of ToxicologyPeer-reviewed·Feb 17, 2026
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Integration of In Vitro and In Silico Approaches Enables Prediction of Drug-Induced Liver Injury
René Geci, Ahenk Zeynep Sayin, Stephan Schaller, Lars Kuepfer
Dividing Cmax by lowest in vitro toxicity potency separates drugs by liver-injury (DILI) risk, AUC up to 96%; PBK-predicted Cmax without clinical data reaches 91%.
5 citationstop 1%
human·bulk RNA-seq
·𝕏 Post·Bluesky