Drug-Induced Hepatotoxicity and Protection

Differential Protection against Acetaminophen-induced Liver and Kidney Injury by N-Acetylcysteine and Fomepizole in Female Mice

This study compares the protective effects of NAC and Fomepizole against APAP-induced liver and kidney injury in female mice, showing Fomepizole provides broader protection.

High-Throughput Morphological Profiling of Patient-Derived Human Liver Organoids for Hepatotoxicity Hazard Identification and Compound Prioritization

This paper uses patient-derived liver organoids and machine learning to identify hepatotoxic compounds by analyzing morphological changes, achieving high accuracy in distinguishing toxicants from non-toxicants.

Hepatotoxicity assessment of antimalarial compounds from microorganisms using a liver organ-on-a-chip system

This study evaluates the hepatotoxicity of three antimalarial compounds using a liver organ-on-a-chip system, finding that NATPP0604 has a superior safety profile compared to the others.

Non-invasive quantification of hepatic necrosis from circulating alanine aminotransferase kinetics in acetaminophen-treated mice in vivo

This study uses serial ALT kinetics to estimate hepatic necrosis in vivo in acetaminophen-treated mice, showing better prediction accuracy than traditional methods and reducing animal use.

Towards Bayesian-based quantitative adverse outcome pathways using in vitro data from open literature and continuous variables: a case example for liver fibrosis.

This paper develops a Bayesian-based model using in vitro data and continuous variables to predict liver fibrosis by analyzing key markers of hepatic stellate cell activation.

Cell line identity rather than medium composition determines transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media: comparison with primary human hepatocytes

This study compares transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media, finding that cell line identity, not medium composition, is the main determinant of transcriptomic variance.

Novel apoptosis signal-regulating kinase 1 (ASK1) inhibitor SRT-015: Potential therapeutic for multiple liver diseases

This paper evaluates SRT-015, a novel ASK1 inhibitor, showing its efficacy in multiple liver disease models without safety concerns.

Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen Overdose

This study shows that activating the Adenosine A2B Receptor after acetaminophen overdose accelerates liver recovery by enhancing lipid metabolism and immune responses.

Sublethal stress from polypharmacy modulates scavenging function and fenestrations in mouse liver sinusoidal endothelial cells

This study examines how polypharmacy affects liver sinusoidal endothelial cells, showing drug- and concentration-dependent changes in fenestrations and endocytosis.

Hepatic cellular stress response pathways exhibit species differences in basal and inducible activity

This study compares hepatic stress response pathways in humans and preclinical animal species, finding rodents have greater basal and adaptive capacity for mitigating chemical insults.

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice

This study shows that HuR deficiency in male mice increases susceptibility to APAP-induced liver injury by impairing xenobiotic metabolism and mitochondrial function.

Differential effects of fenofibrate and fenofibric acid on the regulation of liver endothelial permeability

This paper investigates how fenofibrate and its metabolite fenofibric acid affect liver endothelial permeability, finding fenofibrate reduces fenestration and mechanical properties while fenofibric acid does not.

Integration of In Vitro and In Silico Approaches Enables Prediction of Drug-Induced Liver Injury

Dividing Cmax by lowest in vitro toxicity potency separates drugs by liver-injury (DILI) risk, AUC up to 96%; PBK-predicted Cmax without clinical data reaches 91%.

Diploid Hepatocytes Resist Acetaminophen-Induced Liver Injury Through Suppressed JNK Signaling

The paper shows diploid hepatocytes are more resistant to acetaminophen-induced liver injury due to reduced JNK signaling and mitochondrial damage.

Oxidation-Driven mtDNA B-Z Transition Activates ZBP1 to Mediate Acetaminophen Hepatotoxicity

This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.

LRBA promotes drug-induced liver injury and MASLD by scaffolding MAPK activation

This study identifies LRBA as a scaffold promoting MAPK activation, leading to drug-induced liver injury and MASLD by enhancing inflammatory signaling.

Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

This study shows that co-culturing iPSC-derived macrophages with hepatocytes enhances macrophage maturation and hepatocyte function through direct cell-cell contact.

Insights into the protective mechanisms of N-acetyl cysteine against D-Galactosamine induced acute liver injury in rabbits

This study investigates the protective effects of N-acetyl cysteine (NAC) against D-Galactosamine-induced acute liver injury in rabbits using both in vivo and in vitro models.

EFFECT OF METHANOL STEM-BARK EXTRACT OF Erythrina senegalensis ON SERUM ALBUMIN LEVEL OF CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN WISTAR ALBINO RATS.

This study evaluates the effect of methanol stem-bark extract of Erythrina senegalensis on serum albumin levels in carbon tetrachloride-induced liver damage in rats, finding that it restores serum albumin and reduces liver necrosis.

Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in Aldh2*2 knock-in mice

This study shows that Aldh2*2 knock-in mice exposed to allyl alcohol experience a systemic aldehyde storm leading to hepatic ferroptosis due to impaired aldehyde detoxification.

Degradation rather than disassembly of necrotic debris is essential to enhance recovery after acute liver injury

This study shows that enzymatic degradation of necrotic debris improves recovery after liver injury, while disassembly strategies like peptide treatment or plasmin activation are less effective or harmful.

The Lipidome Landscape of Amiodarone Toxicity: An in vivo Lipid-centric Multi-Omics Study

This study investigates amiodarone toxicity in rats using lipidomics and transcriptomics, revealing significant lipidome and gene expression changes associated with hepatotoxicity.

Endoplasmic reticulum stress inhibition preserves mitochondrial function and cell survival during early onset of isoniazid-induced oxidative stress

This study investigates INH-induced hepatotoxicity, showing ER stress inhibition can mitigate oxidative stress and mitochondrial dysfunction during early exposure.

Protective Effect of 2-Hydroxyestrone and2-Hydroxyestradiol Against Chemically-Induced Hepatotoxicity In Vitro and In Vivo

This study shows that 2-hydroxyestrone and 2-hydroxyestradiol protect against ferroptosis in hepatoma cells and acetaminophen-induced liver injury by inhibiting PDI activity and reducing NO, ROS, and lipid-ROS accumulation.

Fatty acid-mediated induction of CYP2E1 activity in HepaRG cells is not systematically associated with exacerbated acetaminophen cytotoxicity

This study shows that increased CYP2E1 activity from fatty acids in HepaRG cells does not always lead to greater acetaminophen toxicity, as only certain fatty acids exacerbate liver damage.

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions

This study develops hepatocyte-like liver organoids (HeLLOs) that closely mimic mature hepatocyte functions and outperform existing models in drug toxicity testing and disease modeling.

Acetaminophen Overdose Reveals Protease-Activated Receptor 4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium

This study investigates the role of protease-activated receptors 1 and 4 on hepatic endothelial cells during acetaminophen overdose, finding that low-expressing PAR4 is a potent receptor with functional redundancy to PAR1.

Early brain neuroinflammatory and metabolic changes identified by dual tracer microPET imaging in mice with acute liver injury

The potential role of taurine in acetaminophen hepatotoxic induced rats

This study investigates taurine's protective effects against acetaminophen-induced liver injury in rats, finding that taurine administration before or after acetaminophen reduces hepatocyte necrosis.

Multicellular, fluid flow-inclusive hepatic in vitro models using NANOSTACKS™: a human-relevant model for drug response prediction

This study introduces NANOSTACKS™ as a novel in vitro platform to create human-relevant hepatic models for drug response prediction, showing improved DILI screening capabilities compared to conventional models.