Lymphatic System and Diseases

This study shows that VEGF-C promotes brain infarcts after stroke, while blocking VEGFR-3 improves outcomes, highlighting a dual role for VEGF-C in stroke recovery.

This study shows that periodic hyaluronidase injections improve lymphatic drainage and reduce fibrosis in a rodent model of vascularized lymph node transfer for secondary lymphedema.

This study characterizes the molecular changes in adipose tissue from breast cancer patients with secondary lymphedema, finding distinct transcriptomic profiles compared to obesity.

This study identifies mesenchymal Osr1+ cells as regulators of embryonic lymphatic vessel formation by controlling LEC proliferation and migration.

This study shows CGRP and AM2/IMD induce p44/42 MAPK phosphorylation in primary human dermal lymphatic endothelial cells, with CGRP having a sustained effect.

The paper identifies Angpt1/Tie1 signaling as essential for trunk lymphatic vessel development in zebrafish, showing Tie1 regulates Foxo1 localization and modulates Vegfc/Vegfr3 signaling.

This study identifies Zmiz1 as a regulator of lymphatic endothelial cell function and Prox1 expression, showing its role in lymphatic vessel development and valve formation.

This study identifies multiple cis-regulatory elements controlling prox1a expression in distinct lymphatic vascular beds in zebrafish.

This study shows decorin suppresses tumor lymphangiogenesis by inhibiting VEGFR3 and reducing lymphatic vessel markers, suggesting it as a potential therapeutic for breast cancer.

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

This study identifies Sorbs1's role in zebrafish lymphatic and venous vessel development, showing it regulates cytoskeleton dynamics and BMP signaling, distinct from Vegfc pathways.

This study uses single-cell RNA sequencing to characterize renal lymphatic endothelial cells' response to acute kidney injury and identifies gene expression changes across different injury models.

The paper identifies penile cavernous sinusoids as hybrid vessels expressing lymphatic markers and shows their functional and molecular characteristics in health and disease.

This study creates a single-cell transcriptomic atlas of lymphatic muscle cells in mice across ages, revealing age-related transcriptional changes and a pro-inflammatory environment in aged cells.

The paper identifies a novel population of cardiac lymphatic endothelial cells in human fetal hearts associated with coronary arteries using single nuclei multiomic analysis.

This study identifies lymphatic muscle cells as the pacemaker cells in mouse collecting lymphatic vessels through combined immunofluorescence, scRNA-seq, and electrophysiological analyses.

The paper uses 3D imaging to study the vascular development of the mouse epididymis, revealing the organization of blood and lymphatic networks during development.

This study identifies a genetic interaction between svep1 and tie1 in zebrafish lymphatic development, independent of Vegfc, and links it to human glaucoma.

This study uses single-cell transcriptomics to investigate Prox1's role in lymphatic endothelial cell fate specification and differentiation in zebrafish, identifying new transcriptional targets and regulatory mechanisms.

This study identifies SOX7 as a transcription factor in blood vascular endothelial cells that represses Vegfc expression, influencing lymphatic vessel patterning in mice.

This study conducts a GWAS on a UK lipoedema cohort, identifying genetic loci associated with the disease, including those related to lipoma formation and hormone biosynthesis.

This study identifies the cardiopharyngeal mesoderm as a non-venous source of lymphatic endothelial cells contributing to craniofacial and cardiac lymphatic networks.

The paper uses lineage tracing to show that dermal lymphatic vessels can originate from sources other than the Cdh5 lineage, highlighting the importance of temporal control in lineage tracing.

This study identifies that arterial mural cells provide survival and guidance cues via Cxcl12a/b and Vegfc to promote lymphatic endothelial cell migration in zebrafish.

This study shows that meningeal lymphatic networks are impaired in craniosynostosis models, leading to reduced lymphatic drainage and potential waste clearance issues in the central nervous system.

The paper identifies the role of asymmetric Pitx2 in intestinal lacteal development and shows its protective effect against fatty liver disease through lymphatic-dependent lipid transport.

This study identifies distinct roles for Notch4 and canonical Notch signaling in embryonic dermal lymphangiogenesis using mouse models.

This study shows that urgent brain vascular regeneration after ischemic stroke occurs through lymphatic transdifferentiation, mediated by EphrinB2a/EphB4a/Notch signaling in zebrafish.

This study identifies a genetic interaction between Pkd1 and Wnt5a in controlling lymphatic vascular morphogenesis in mice, showing mutual suppression of lymphatic defects.

This study shows that Vasohibin-1 mediates tubulin detyrosination in zebrafish endothelial cells, selectively regulating secondary sprouting and lymphangiogenesis in the trunk.